ID H9G5C6_ANOCA Unreviewed; 568 AA.
AC H9G5C6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Transglutaminase-like domain-containing protein {ECO:0000259|SMART:SM00460};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001543.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000001543.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001543.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000001543.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
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DR AlphaFoldDB; H9G5C6; -.
DR STRING; 28377.ENSACAP00000001543; -.
DR Ensembl; ENSACAT00000001580.4; ENSACAP00000001543.4; ENSACAG00000001559.4.
DR eggNOG; ENOG502QQ46; Eukaryota.
DR GeneTree; ENSGT01050000244939; -.
DR HOGENOM; CLU_013435_2_2_1; -.
DR InParanoid; H9G5C6; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000001559; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF70; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 1.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 181..272
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 189
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 246
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 269
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 309
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 311
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 361
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 366
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 568 AA; 64318 MW; 43584AF33B791DF3 CRC64;
FSGSSPRKPK GRYLFPLNQA NCFIAVTSPA DAIIGKYGLD VITESNVCDP GKNFIYVLFN
PWCKADSVFM PGDAQKAEYV LNATGFQYRG RTEDIYPMPW HYGQFEEEIL DCCMYLLHKS
ELGPNDRRDP IMIARAMSAM VNMKDDKGVI FGKWKRPYIN GTNPSHWKGS VRILQQYYRT
KKTVFYGQCW VFSGVLTTVM RCLGIPARSV TTTSAGRDTE GNINVDIYYN EKKEQLRDGD
FTWAFHVWND VWMKRPDLPE GHDGWQALDG TPLEKSEGIF RCGPASVKAI KYGKVNLDYD
AMLLFSAVNA DKVYWRIENV NGEDKYINYK EESKEVGKEI LTKAIGKDTH EDIKDEYKFP
EGSDEERKAM ATAMSYVKDR NRAADQVFKS FKASIELGCT EEKVVLTGQP IHLNITIKSK
SGDAQVVNLS AFCHLESYIG EIEARLGTIQ QTVQAEGKTV IQVPLKIPAD AYMKVLSQTE
DQLLVKVNIF ANIQETNEKL IKTLTLPFLY PKLNVVVRNK RLDINSLGRL NQDIVKDVAS
NSNVAQTAGK PLLSHKYKHE IMLFSLTN
//
