ID   H9G5Q4_ANOCA            Unreviewed;       404 AA.
AC   H9G5Q4;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Archaelysin family metallopeptidase 2 {ECO:0000313|Ensembl:ENSACAP00000001821.3};
GN   Name=AMZ2 {ECO:0000313|Ensembl:ENSACAP00000001821.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001821.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000001821.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001821.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000001821.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC       {ECO:0000256|ARBA:ARBA00010405}.
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DR   AlphaFoldDB; H9G5Q4; -.
DR   STRING; 28377.ENSACAP00000001821; -.
DR   Ensembl; ENSACAT00000001865.3; ENSACAP00000001821.3; ENSACAG00000001881.3.
DR   eggNOG; KOG0082; Eukaryota.
DR   GeneTree; ENSGT00530000063996; -.
DR   HOGENOM; CLU_014184_3_1_1; -.
DR   OrthoDB; 2897309at2759; -.
DR   TreeFam; TF300673; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000001881; Expressed in adrenal gland and 13 other cell types or tissues.
DR   GO; GO:0031526; C:brush border membrane; IBA:GO_Central.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR   GO; GO:0031752; F:D5 dopamine receptor binding; IBA:GO_Central.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   CDD; cd00066; G-alpha; 1.
DR   Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000469; Gprotein_alpha_12/13.
DR   InterPro; IPR001019; Gprotein_alpha_su.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR   PANTHER; PTHR10218:SF85; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-13; 1.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00440; GPROTEINA12.
DR   SMART; SM00275; G_alpha; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR   PROSITE; PS51882; G_ALPHA; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ   SEQUENCE   404 AA;  46637 MW;  1CC9DB52F124CA29 CRC64;
     MADFLPSRSS LSVCFPSCLL NSSEAEQQRK SKEIDKCLYR EKTYVKRLVK ILLLGAGESG
     KSTFLKQMRI IHGEDWDRSA REDFRATIYS NVLKGVRVLV DAREKLHIPW GNPANQTNGD
     KLMAFDTRSG VAVQGMVETE VFLQYLPAIR SLWTDSGIQH AYDRRREFQL GESIKYFLDN
     LDKLGEPDYL PSQQDILLAR RPTKGIHEYD FQIKNVPFKM VDVGGQRSER KRWFECFDSV
     TSILFLVSSS EFDQVLMEDR QTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV
     QKMKVIKHSE EALKLALISK DKKLVKLYEN LEPKEKLLLS QAFQPGSVLF KTITLHSESD
     WISSHPEPTQ DFAQFYHDPH RNTPSPQKNR IYVQPIGNVP LISQ
//