ID H9G676_ANOCA Unreviewed; 721 AA.
AC H9G676;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=TRMT1-like protein {ECO:0000256|ARBA:ARBA00015939};
GN Name=TRMT1L {ECO:0000313|Ensembl:ENSACAP00000002310.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000002310.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000002310.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000002310.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000002310.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in motor coordination and exploratory
CC behavior. {ECO:0000256|ARBA:ARBA00003652}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000256|PROSITE-ProRule:PRU00958}.
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DR RefSeq; XP_003223453.1; XM_003223405.3.
DR AlphaFoldDB; H9G676; -.
DR STRING; 28377.ENSACAP00000002310; -.
DR Ensembl; ENSACAT00000002370.4; ENSACAP00000002310.3; ENSACAG00000002342.4.
DR GeneID; 100556004; -.
DR KEGG; acs:100556004; -.
DR CTD; 81627; -.
DR eggNOG; KOG1253; Eukaryota.
DR GeneTree; ENSGT00530000063646; -.
DR HOGENOM; CLU_010862_3_0_1; -.
DR InParanoid; H9G676; -.
DR OrthoDB; 3146970at2759; -.
DR TreeFam; TF300851; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000002342; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0002940; P:tRNA N2-guanine methylation; IBA:GO_Central.
DR Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10631:SF1; TRMT1-LIKE PROTEIN; 1.
DR Pfam; PF02005; TRM; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00958};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; tRNA processing {ECO:0000256|PROSITE-ProRule:PRU00958};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 186..206
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 81085 MW; 97BDC86762F132AB CRC64;
MADGKTAALL LLGLPPQPPP EAGEEEEESE QPNGTDDSVK PESHRPDVET IEDEVKIEKE
ETEQESIKEP NTNLLDALSS SLREKHISIQ RTLADLEKLA GLKEGCLTTV TSENSGDKKL
CPLCPEERFK ACSGHKLYRH LQNLHWKVSV EFEGYRMCIC HLPCHPVKPN VTADPISAKM
GSHYHCLICS ATIGRRTDMI GHVKRHVNKG ETESRFMSAP KSSCEIVKEA DTDVHVLPNY
TTPQKTDSYF NPKMKLNRQL TVCALAVLAE ERKPLECLDA FGATGIMGLQ WAKHLGNSVK
VTINDYNEKS VTMIQENCHL NKMKVVMNLR EEEDCDEAVE EVEENLPVIE VTKMDANVIM
HLRAFDFIHL DPFGSSVNYL DAAFRNVRNL GIVSVTSTDI SSLYSKAQHV AQRHYGSNIV
RTEYYKELAA RMIIAAVARA AARCNKGIEV LLAVALEHFV LVEVRVLRGP SPADDTAKKI
RYLIHCQWCE ERVFKKEGNM IEENPYRQLP CDCHSRMTGK TAIELGPLWS GSLFNTGFLR
RMLFEAVQYG LEDIQPLLKT LICEAECTIL KQFSIHGPSN QNKQEECGVI IKTPDATAEY
FVVHGKRTSN EVSQNGAKRQ KLESNAEHPS FYYNIHRHSI KGMNMPKLNK FLHYLSEAGY
RVSRTHFDPM GVRTNAPLVQ FKSILVKYST PTYTGGPTES PLHCSEDSQP VTESDFAEEN
I
//
