ID H9G6W1_ANOCA Unreviewed; 991 AA.
AC H9G6W1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSACAP00000002857.3};
GN Name=RUBCN {ECO:0000313|Ensembl:ENSACAP00000002857.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000002857.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000002857.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000002857.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000002857.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008118209.1; XM_008120002.2.
DR AlphaFoldDB; H9G6W1; -.
DR STRING; 28377.ENSACAP00000002857; -.
DR Ensembl; ENSACAT00000002928.4; ENSACAP00000002857.3; ENSACAG00000002827.4.
DR GeneID; 100567356; -.
DR KEGG; acs:100567356; -.
DR CTD; 9711; -.
DR eggNOG; KOG1829; Eukaryota.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000160658; -.
DR HOGENOM; CLU_013778_0_0_1; -.
DR InParanoid; H9G6W1; -.
DR OrthoDB; 126314at2759; -.
DR TreeFam; TF317067; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000002827; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0141039; F:phosphatidylinositol 3-kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:1901097; P:negative regulation of autophagosome maturation; IBA:GO_Central.
DR GO; GO:0045806; P:negative regulation of endocytosis; IBA:GO_Central.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 30..167
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 229..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 510..540
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 229..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 110076 MW; F84C80EF9DA117FA CRC64;
MEAGKEHWKL LGSLKSTVEG LVSISNPNVW SKYGGLQRLC RDMHGILYHG LIPDKVCCQQ
RDYWHFVKDI RWLSPNAAHH VEKFISLHEN GQRNADRAIA ELWLQHSLQF HCLSAQLKPL
LENKQYVRKF YADSAFLLSD AHVTVMLQCL EAVEQNNPRL LAQIDASMFA RKSEVSMPMT
KSQSLTALPG SMCIPPAEST TPCYFGSFSG VHTAAASIQD RRFSSTLVCS SSSSQPQENA
PCASSSHWQP EGRSPPRLIA PQLTVSCPKD SSPTGEMSAT GTSVDPSDDP WAGGQDDTDG
PEYLAIGNLG RQSRSCDSPS ESNAATPNSA GSSTSNLFSS SSSQKPESLS SLSEHGASGG
SSSSVRGTSI LRRSSFSEGQ TLAPPGTLRR SHMRSHSDTN VASGRAHGGH RDMSIIIEDP
VAESNGDISQ FKGGMSCSMQ RGEVSSPGSV YVEYDTGQYL HSGEGMFRRP SEGQSLISYL
SEQDFGSCAD LEKENAHFSI CESLIAAIEL MKCNMKNRQL EEEEEDSDKE IQELKQKIRI
RRQQIRTRNL HPAYEEIGSD SLLATDSGSH FSSRDSARLS DSGSAEEVDE YEIKDGNDGS
NLIQLSKSGL SVSMASLFSD EDIKRSSAPS RKAFHFSGST FHSFLNSNSA EAVAMGLLKQ
FEGMQLPAAS ELEWLVPEHD APQKLLPIPD SVPISPDDGE HADIYKLRIR VRGNLEWAPP
RPQIIFNIHS APTRKVAVAK QNYRCAGCGI RTDPDYIKRM RYCEYLGKYF CQCCHENAQM
VIPSRILRKW DFSKYYVSNF SKDLLTKIWN DPLFNVQDIN PGLYRKVKPL NQVRLLRIQL
YHMKNMFKTC RFAKTLLDAF DAVPGHLTED LHLYSLNDLG ATKKGELLPR LSELLRAGSL
HVEKCMLCQA KGFICEFCQN EDDIIFPFEL NKCRTCEECR ACYHKICFRS GPCPKCKRLQ
ARRELLAKQS MEADLSDYED GQEEDAAGAA T
//
