ID H9G786_ANOCA Unreviewed; 737 AA.
AC H9G786;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003147.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000003147.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003147.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000003147.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9G786; -.
DR STRING; 28377.ENSACAP00000003147; -.
DR Ensembl; ENSACAT00000003228.3; ENSACAP00000003147.3; ENSACAG00000003235.3.
DR eggNOG; KOG4345; Eukaryota.
DR GeneTree; ENSGT00940000159172; -.
DR HOGENOM; CLU_013263_0_0_1; -.
DR TreeFam; TF323312; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000003235; Expressed in ovary and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd14347; UBA_Cezanne_like; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR13367:SF9; OTU DOMAIN-CONTAINING PROTEIN 7A; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 692..727
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT REGION 66..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 79928 MW; 7FB8500BE6E25540 CRC64;
KVTGELLVQD PMTLEMDVVL SDFVRSTGAE PGLARDLLEG KNWDLSAALS DFEQLRQVHA
GTLPHAFPEG RAFKPPEKEA PRPTRPVLQR QDDIVQEKRL SRGISHASST IVSLARSHVS
SNGSNGGSNG GGEHLLEMPI CTFQLPDLTI YNEEFRTFIE RDLIEQSMLV ALEQAGKEGP
EMGYTGHGPS CVVEGFHGRN NNNNNNNNNN NNNNNNNTTS AGGSSGNTVK PLLKAYVSLA
AFAPIPFGGI YLPLEVPASK CHRSPLVLAY DQAHFSALVS MEQKEPSKEQ AVIPLTDSEH
KLLPVHFAVD PGKDWEWGKD DGDNVRLASV TLSLEAKLHL LHSYMNVKWI TLPCDTPRPL
PPGTMPRSAA DSGDSDKESV CSSSASNSGG SKSGGGGKDK EKDKPKKDRE REKEKKRADS
VANKLGSFGK TLGSKLKKNM GGLMHSRTAK GAGLANGQGD ATLEKKQKKQ KGSIKVRKGS
KDEGTSAGES ESPSERSCPA KAASEKPADT TCKYGSDIKL SLGILRAAMQ GERKFIFTGQ
LKTSHRHQYQ EEMIQRYLAD AEERFSAEQK QREAEKKMAA LSNGGGRRPD SECSPLRGED
ALPNPTYSPP ALSPYGLQTR RRPLRPPPLL RHAAPALRPR AAPSPLPSRP SALGRANGYR
EYHEPGGGGG SAGGSPKGIV VDPNKARFLY GGVQQTKCKQ PNCSFYGHPE TGNYCSCCYK
EELKRKEREP GALTHRF
//
