ID   H9G7P3_ANOCA            Unreviewed;       759 AA.
AC   H9G7P3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Prominin 2 {ECO:0008006|Google:ProtNLM};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003446.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000003446.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003446.4};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000003446.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC       {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
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DR   AlphaFoldDB; H9G7P3; -.
DR   STRING; 28377.ENSACAP00000003446; -.
DR   Ensembl; ENSACAT00000003532.4; ENSACAP00000003446.4; ENSACAG00000003505.4.
DR   eggNOG; KOG4331; Eukaryota.
DR   GeneTree; ENSGT00530000063586; -.
DR   HOGENOM; CLU_008293_2_0_1; -.
DR   InParanoid; H9G7P3; -.
DR   TreeFam; TF324631; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000003505; Expressed in hindlimb bud and 5 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR   GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071914; C:prominosome; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF6; PROMININ-2; 1.
DR   Pfam; PF05478; Prominin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        396..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        705..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   759 AA;  85872 MW;  1E516C38217A9C68 CRC64;
     MLTTQDEKSQ RCVVFSSSHP LQILQYQTGY LVCATIAVIY FVALPAVGLS LCCCGRRRRC
     GGRVKAYRRS LRCQRNLLML GLLLTTLVIL AGVVCAFAAN QRVKEEMEPG SRDALNTLQA
     LRRHVNGIPQ GVQRAVDEVA VPKEQILQDL DNVGRSIGST IQLVLKGTVY LAMAAMKGRV
     QDLQNSLHHL RTVNTTVQAL IRHQDELEST LKERKESIVF LLKDPRCAYC QSAFNRAESL
     ELGVNYRRVP SVEKELKTLH GLPKTNFTEM IERANRSFNS IPEVAGAKMA EVVRDLKAEI
     EKAARKVQSI ADGFPILEHT RLMNDALAKA ENHSRPYFKE VKHYEKYRWI VGVVACTVVL
     LIVFCNLLGL SLGLYGLTVR EDPSDYESRG EAGAKLLLTG IGFSFLFSWL LILLVFGTFL
     VGGNVQTLVC KHWASQEIYK FIDTPGNLPA SMNISQHLGL KKNLNITTAY QQCKNGAGFW
     EVLHLEDRYN LNEHLHLAKY TTEFQKRLGR FQTRFEDIVL LNAEGRKDLE TFRDSRIDLI
     DYPAFTAEMR NPMVRTNLEG LAGDLERLST VQSDRTVAER LAEEAWKLKE IQNTMVLLME
     GMVVTVSSPP NIEFLLFLLP FHQILINSTE SQAGHAETAI PLESQKILQQ ELSCFERKEV
     GYVSQYLNWL RIVLIEDVAS CLPFSAALDN GRVILCDRIA DPWNAFWFSL GCCTIFLILS
     IFFAIKTMKH FRPIRHRLVS TGSEETYPFH IPRVTSLRL
//