ID H9G937_ANOCA Unreviewed; 551 AA.
AC H9G937;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN Name=LOC100556863 {ECO:0000313|Ensembl:ENSACAP00000004364.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004364.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004364.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004364.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004364.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003228769.1; XM_003228721.3.
DR AlphaFoldDB; H9G937; -.
DR STRING; 28377.ENSACAP00000004364; -.
DR Ensembl; ENSACAT00000004464.3; ENSACAP00000004364.2; ENSACAG00000004340.3.
DR GeneID; 100556863; -.
DR KEGG; acs:100556863; -.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000163547; -.
DR HOGENOM; CLU_001839_3_1_1; -.
DR InParanoid; H9G937; -.
DR OMA; CASYPPA; -.
DR OrthoDB; 5474662at2759; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000004340; Expressed in adrenal gland and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR CDD; cd13211; PH-GRAM_MTMR9; 1.
DR CDD; cd14536; PTP-MTMR9; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807:SF52; MYOTUBULARIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 125..498
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 528..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 62224 MW; 08EF4F429F6F6CD9 CRC64;
MEFAELIKTT KVDNVVFSHP GLEPVAGTLC ITSHHLLLSG SREQNQIELW LLIRNVDAIE
KRLANSSCSL TLKCKDLKVL HLEIPGMEEC LNVASSIEAL SSVESVMMMY PFFYRPQSMR
LAGGGRQPHA LEKYYQQVAS RTGAWRLSVV NEDFQACPSY PALVVVPSSV DDAALRKSAR
FRQGGRFPVL SYYHKKNGTV MLRSSQPLVG PHRKRCPEDE GLLAAALDGR SRGFVLDTRS
AQAAKQAKMM GGGTEHRSAY AGWKRMHRAL DRGRPLQESF VKVVETCNDP SLTMDRWLSK
LEASKWLTHV KESLGTACLA AQCMEREEAC VLVHGAEGMD TTLLVTALAQ VILDPCRRTM
AGFQELLEQE WIQAGHPFHL RCARSAYSHA RLKQESPVFL LFLDCVWQLG RQFPLSLEFN
EAFLLALFEH SYASPYGTFL CNNEKERKLC NVEGKTHSLW PWIHSERQKF LNPLFAPNPL
VIWPSVEPQS IFLWQGLFLR WVRSSHYIDE AWTEIQKIAR NHKAHLEHQS GAASTQTEAQ
TLSKVETNAH L
//
