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Database: UniProt
Entry: H9G944_ANOCA
LinkDB: H9G944_ANOCA
Original site: H9G944_ANOCA 
ID   H9G944_ANOCA            Unreviewed;       146 AA.
AC   H9G944;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   05-JUN-2019, entry version 33.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|RuleBase:RU364145};
DE   AltName: Full=Mediator complex subunit 9 {ECO:0000256|RuleBase:RU364145};
GN   Name=MED9 {ECO:0000256|RuleBase:RU364145,
GN   ECO:0000313|Ensembl:ENSACAP00000004374};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004374, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000004374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004374};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000004374}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364145, ECO:0000256|SAAS:SAAS00869477}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364145,
CC       ECO:0000256|SAAS:SAAS00869478}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000256|RuleBase:RU364145}.
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DR   EMBL; AAWZ02029231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 28377.ENSACAP00000004374; -.
DR   Ensembl; ENSACAT00000004474; ENSACAP00000004374; ENSACAG00000004505.
DR   eggNOG; ENOG410J0JM; Eukaryota.
DR   eggNOG; ENOG4111U35; LUCA.
DR   GeneTree; ENSGT00390000017379; -.
DR   InParanoid; H9G944; -.
DR   OMA; NVIKCMD; -.
DR   TreeFam; TF324926; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000004505; Expressed in 4 organ(s), highest expression level in heart.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364145};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Nucleus {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869474};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transcription {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869482};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869473}.
FT   REGION        1     63       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H9G944}.
FT   COILED      118    138       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     13     59       Polar. {ECO:0000256|MobiDB-lite:H9G944}.
SQ   SEQUENCE   146 AA;  16240 MW;  05AA9EC363665931 CRC64;
     AGPPPLPAPP QQQQAQQPTS QPPQQQQQPS PAEAKFQAPA QPPAQSSAPQ ASPTAAPPSH
     EQASFLPLVH DVIKCMDKDS QDVHQMLNEL RTKFVEMRKL IKSMQGIGMS PEQQQVQLQN
     LREQVKTKSE LLQKYKSLCM FEIPKE
//
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