ID H9G9C5_ANOCA Unreviewed; 791 AA.
AC H9G9C5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=RAS protein activator like 1 {ECO:0000313|Ensembl:ENSACAP00000004554.4};
GN Name=RASAL1 {ECO:0000313|Ensembl:ENSACAP00000004554.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004554.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004554.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004554.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004554.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9G9C5; -.
DR STRING; 28377.ENSACAP00000004554; -.
DR Ensembl; ENSACAT00000004659.4; ENSACAP00000004554.4; ENSACAG00000004572.4.
DR eggNOG; KOG2059; Eukaryota.
DR GeneTree; ENSGT00940000158715; -.
DR HOGENOM; CLU_008096_0_0_1; -.
DR InParanoid; H9G9C5; -.
DR TreeFam; TF105302; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000004572; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR GO; GO:1903861; P:positive regulation of dendrite extension; IEA:Ensembl.
DR CDD; cd13369; PH_RASAL1; 1.
DR CDD; cd05135; RasGAP_RASAL; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037776; RASAL_RasGAP.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..114
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 125..243
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 311..521
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 581..688
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 791 AA; 89741 MW; 85C2ACC6FBBB696D CRC64;
KARNVCLEIR GRGRIPDILA AGLSPNDATD KSGTSDPYCI IKVDNEVVAR TATIWKNLNP
FWGEEYTLHL PMGFHNLSFY VLDEDTIGHD DVIGKITLSK ETISSNPKGI DRWINLSCVD
PNEDVQGEIS LEIQIVEEED HKRALCCHVI EARDLAPRDI SGTSDPFARI LWNGQALETA
IIKKTRFPHW DEMLEFVLEE GVAGETPLVI EVWDWDMVGK NDFLGRVEFS LDALQKAPPK
GWYRLLPFPS AEEDAGGKLG ALRLRIRLSE DRILPSRYYQ PLVDLLVESV LCPEDDVTPI
TLLEDVCSME SRQDVATKLV KIFLGQGLVV PFLGCVNLCE ISRTTDPNTL FRSNSLASKS
MEQFMKVVGM PYLHEVLKSV INRIFEEKKY VELDPCKIEP SRTRRISFKG SLSEAQIRES
SLEVLKGYLK DIIHGIVNST QKCPTAMRVA FKQLHKQVAD RFPEAENQEA KYIAISGFIF
LRFFAPAILT PKLFNLRDQH ADTQTSRTLL LLAKAVQSIG NLGLQIGHGK EQWMEPLHPF
ILASIERVKE FLDRLIDVDS ENGEGKISRE KQPWTLFHPS ATIKEGYLHK RRAEGLPLVS
RFTFKKRYFW LSKESLSYSK SPEWQVRTSI PVQRICAVER VDENAFQQPH VMQITTRDAG
GQVLTTYIQC KNVNELNQWL SAIRKVTVSN DCMLPFCHPG TFRGNRWTCC LQTDRAAHGC
SRTHSAVTLG DWNDPLDPDT EAQMVYKHLL LGRDKLRSVE DDLLLSIKGI SIVKHLFVLT
CTITIVWRLG C
//
