ID H9G9W2_ANOCA Unreviewed; 502 AA.
AC H9G9W2;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=T-box transcription factor 5 {ECO:0000313|Ensembl:ENSACAP00000005017.3};
GN Name=TBX5 {ECO:0000313|Ensembl:ENSACAP00000005017.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005017.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005017.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005017.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005017.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; H9G9W2; -.
DR STRING; 28377.ENSACAP00000005017; -.
DR Ensembl; ENSACAT00000005130.4; ENSACAP00000005017.3; ENSACAG00000005111.4.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000156506; -.
DR HOGENOM; CLU_037025_1_0_1; -.
DR InParanoid; H9G9W2; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000005111; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR GO; GO:0003167; P:atrioventricular bundle cell differentiation; IEA:Ensembl.
DR GO; GO:0060928; P:atrioventricular node cell development; IEA:Ensembl.
DR GO; GO:0060929; P:atrioventricular node cell fate commitment; IEA:Ensembl.
DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR GO; GO:0086054; P:bundle of His cell to Purkinje myocyte communication by electrical coupling; IEA:Ensembl.
DR GO; GO:0003218; P:cardiac left ventricle formation; IBA:GO_Central.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0086019; P:cell-cell signaling involved in cardiac conduction; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR GO; GO:0060039; P:pericardium development; IEA:Ensembl.
DR GO; GO:1903781; P:positive regulation of cardiac conduction; IEA:Ensembl.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0051891; P:positive regulation of cardioblast differentiation; IEA:Ensembl.
DR GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
DR GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
DR GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003163; P:sinoatrial node development; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF28; T-BOX TRANSCRIPTION FACTOR TBX5; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 72..218
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 55568 MW; 73E21E00FB5C4B1A CRC64;
MADAEEGFGL PTTPVEADTK ELGGEGKAEG PATGTPSKPP ASPQAAFTQQ VNIIKILNNH
ANHRWLNSHL PGERMFPSYK VKVTGLNPKT KYILLMDIVP SDDHRYKFAD NKWSVTGKAE
PAMPGRLYVH PDSPATGLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA
FCTHVFAETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM QSKEYPVVPR
STVRQKVASN HSPFSGETRA LSTSSNLGSQ FQCENGVSST SQDLIPPTNP YPVSQEHGQI
YHCTKRKDEE CSTTEHPYKK PYMETSPQED DSFYRSGYSQ QQGLNTSTYR TESAQRQACM
YASSAPATEP VPSLEDISCN TWPPVPSYGS CTVTAMQPMD RLPYQHFSAH FTSGPLMPRL
ATVANHTSPQ IGDTHAMFQH QTAVPHQPIV RQCGPQAGLQ SPTSGLQPAE FLYSHGVPRT
LSPHQYHSVH GVGMVPEWNE NS
//
