ID H9G9W4_ANOCA Unreviewed; 767 AA.
AC H9G9W4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Elongin-A {ECO:0000256|ARBA:ARBA00021346};
GN Name=eloa {ECO:0000313|Ensembl:ENSACAP00000005019.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005019.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005019.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005019.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005019.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
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DR RefSeq; XP_003227608.1; XM_003227560.3.
DR AlphaFoldDB; H9G9W4; -.
DR STRING; 28377.ENSACAP00000005019; -.
DR Ensembl; ENSACAT00000005132.3; ENSACAP00000005019.3; ENSACAG00000005103.3.
DR GeneID; 100562650; -.
DR KEGG; acs:100562650; -.
DR CTD; 6924; -.
DR eggNOG; KOG2821; Eukaryota.
DR GeneTree; ENSGT00390000002428; -.
DR HOGENOM; CLU_021679_1_0_1; -.
DR InParanoid; H9G9W4; -.
DR TreeFam; TF317259; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000005103; Expressed in hindlimb bud and 13 other cell types or tissues.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141:SF75; ELONGIN-A; 1.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 1..78
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT DOMAIN 566..610
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 78..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86619 MW; CC0902FD08DCE95A CRC64;
MAESVLEVVG KLQSRLSGGA EPKKLMKNLK RLSELPITVD ILLETGVGKT VNGLRKHEQV
GDFAKNLVAR WKKLVPVPPE AERHNHEPAD RSYDRSIQRK RQRDPSPKEE EEVEQDYTEA
YQPSCSQSYH LEHGAKKTKR YSEPERAHET VSYDIPEDRT WDRESPVLSD QEGSDYGQTA
SPEPSDVPQE LYVDFCRTEE EEREQKSLHR KAAKGHSFQD RQEGNHSRNF SDAQDKTGSG
RSKEHKSSHK EKQRLETKGE DRAPAFGLER MHKSSSKESA LMGSSKERPK ALDSSKREKK
REGGSAKKEK LHLDSEEALD DHVKKPKHPD SDRAKPEKVK LGDREKVKPE GDSSTKSKEK
KSSGSLKSSE GKPKAPDSHK RTAAFSPPNP GEGEAEDVYE RPTMSFESYL SYDQPQKKKK
KVVKPPPPVV EKEKDRGHGK QNGSKASAKS SDTSQKPQKQ SSEKKAPGVS KAKKIPIDVV
PTLPDIPLPP IQANYRPLPS LESIPLAQPK RKALSSPIEE DEAGFTGRRL NSKMQVYSGS
KTAYLPKMMT LHEQCIRVLS NNIDSIYEVG GVPYSVLEPV LERCTPEQLY RIEECNHVLI
EDTDRLWHIH CVRDFKKEKP EEFESWREMY LRLHDAREQR LLLLTQNIRS AHANKPRGRV
AKMAFVNSAA KPPRDVRRRQ EKFGTGAAAV PERIKIKPVL YMPMKSSHVP AEEEQSYDGP
STSSGHSGPS MGSTSSVSYD PRKPPVKKIA PMMAKTIKAF KNRFSRR
//
