ID H9GAS4_ANOCA Unreviewed; 780 AA.
AC H9GAS4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN Name=LOC100555826 {ECO:0000313|Ensembl:ENSACAP00000005835.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005835.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005835.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005835.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005835.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_003228995.1; XM_003228947.3.
DR RefSeq; XP_008121044.1; XM_008122837.2.
DR AlphaFoldDB; H9GAS4; -.
DR STRING; 28377.ENSACAP00000005835; -.
DR Ensembl; ENSACAT00000005965.4; ENSACAP00000005835.3; ENSACAG00000005930.4.
DR GeneID; 100555826; -.
DR KEGG; acs:100555826; -.
DR eggNOG; KOG0802; Eukaryota.
DR GeneTree; ENSGT00940000165044; -.
DR HOGENOM; CLU_016467_1_0_1; -.
DR InParanoid; H9GAS4; -.
DR TreeFam; TF318635; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000005930; Expressed in ovary and 11 other cell types or tissues.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16476; RING-H2_RNF139-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025754; TRC8_N_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR22763:SF164; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13705; TRC8_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 51..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 533..571
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 576..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 86553 MW; 2690DA51474945BD CRC64;
MASRLEKLAN VVLRVPSIVL LDLLYRWDVQ AFAEGLRPNA QHLYLQRHHL WNIYYAGHVV
CVVVLLLPVR SLVKMYLYLL TVLLLYVGHQ TAWDYIRHEM EHEFYGAVYQ DPVALGRFAT
ALTSQVIVAT LCAFLLRTKQ VWLFAAPMLP LAARLCCLPL QVLPTVNTFA AILTATEALY
IVTSGLSVPF QLVSAAYREV TQALEVYNLV TLGMSLWKQL AVPLLFLVFW LALFTLQIYA
LASSSSGSLL SHQGLIFVLL SSVAECCSTP YSLVGLTFTI SYLALGLLKL CKFYLAGYGA
FQNGNVMHRG VTEGVTLLLL ALQTGLLDLQ LLQRTFLLSI ILFIVVTSTL QSMIEIADPV
LLGLGASRNR SLWKHFRGVS MCLFLLVFPG FMAYKIAHFF HMDFWLLILI SSCMLTSLQV
MGTLFIYGLF IVELFQDAPM ERMDEIIYYV NAVSRVLEFL VALCVVAYGS WESIFGEWSW
MGASVIIIHC YFNVWLRAQS GWRSFLLRRE AAKKIGLLPV ATQEQLQHHD DVCAICFQEM
TLAVVMQCGH FFHGPCLRKW FYVQDTCPLC HQPAQPLANP GSPGGPRVAD PGPEMGGNPV
PEEQDPVSQS STDDSDDSRT PEAGETPREG PGDPSRAFPE GEDLEQCSRS IGGELEENPL
LYTSLLEEAQ TSVSAAESSH GSVQWTAQLA PKAPLELPLG GNSFSSEEPP NPRQEDSPDS
DILPEQSGSI STQRESSSRV PSSLLSEEHL ERPTPDLVPE GHANVLSQSQ DPHASRDLKT
//
