ID H9GBH0_ANOCA Unreviewed; 1762 AA.
AC H9GBH0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Periplakin {ECO:0000313|Ensembl:ENSACAP00000006332.3};
GN Name=PPL {ECO:0000313|Ensembl:ENSACAP00000006332.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006332.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006332.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006332.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006332.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008115008.1; XM_008116801.2.
DR STRING; 28377.ENSACAP00000006332; -.
DR Ensembl; ENSACAT00000006474.4; ENSACAP00000006332.3; ENSACAG00000006410.4.
DR GeneID; 100563033; -.
DR KEGG; acs:100563033; -.
DR CTD; 5493; -.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000153578; -.
DR HOGENOM; CLU_001780_1_0_1; -.
DR InParanoid; H9GBH0; -.
DR OrthoDB; 4241612at2759; -.
DR TreeFam; TF342779; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006410; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF10; PERIPLAKIN; 1.
DR Pfam; PF17902; SH3_10; 1.
DR SMART; SM00250; PLEC; 2.
DR SMART; SM00150; SPEC; 7.
DR SUPFAM; SSF75399; Plakin repeat; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 396..459
FT /note="Desmoplakin SH3"
FT /evidence="ECO:0000259|Pfam:PF17902"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 262..289
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 363..390
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 783..817
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 898..932
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 956..1228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1254..1288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1314..1659
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1762 AA; 206144 MW; B4A930C68D1F17CE CRC64;
MHSLFKKRNK GKYSPTVQKK SISSKELSEL IEKLQKNADQ VERNIVEADT KMQNDLHRLK
AGQSPLYQDH TADKLIESDK LLYVLDGDAA IARHMKHPQG DMITEDIRQL KERVNNLRVK
HDQIYNFTPQ EIEPQVNWST VIDEKQETLN SKGFGTDLPS VNGQVEEHNI FHNEVMAIGP
HISKEGSHAT PVSDEYTSGL QVKYQKLLSG SQQRQQDLNS LQDYMQRCTN KLYWLDQQAK
DRMQYDWSDR NLDYPSRRRQ YENFINRKLE EKEAAINKLH EDGNQLLAEH HPGKIPIEAH
IEAVHADWKE YLNLLICEES HLKFMEDYHQ FQKDAKDAQE LLRKVDTDLD QKYSPDFKDR
YQIESLLQEL EDQEKALDKY DDVVKSLQMR SQQVLPLRYR RETPLKPIPV EALCDYESDQ
CQLSRGARYM LHKNSGDLWE VTDSTGNGIN APGVCFMIPP TDPESLTLAD HIADQYQSVK
QKTAGTKKLL QQRYDTLKAD GAGDAACVQG RQLLAGLEKV NNELDKQEKA ITANLRPPLE
QSRAIQDSAE RSKDLKNIAS EVRHIEPEKG RRIQECEAFV ESVPDASSAA LVKTKVEETN
NKYNHVVQLL GAVQEKVDVA HHLEKSLQQG RDLLSGYENK LAIEDTVPED VRSLERKSEE
LLALGSELQA QRPLLTEAEQ DLQKAKACAG TLAAQFQEHC PDIERQEAEF HKLNQRFGSL
SKQLDHRSQI LQRAKSAYSN YRSGYDNLSQ FLYNMPNYEP QETDNIGQVE TKLRNQRTLL
GEIASKERDA QKISAEAQQY QQAVKDYELE AEKLRSILDL ENGRNGFMSK RPRLQSPAAK
VKEEEAVLAA KFTEVNAVNR QRLQNLEFAQ NLLKQQPDVQ LMQESVQSSR SERPLEEIWK
LRKELEDESQ RRQQLEEEIK VIQENILLLQ NQKPQESLVT KEVVKKVPDP QLEDSFYKMQ
QNFAEEQRKN QELQNELEAL KLKLRTLEHE KREGAQEYVV KEVLRIEPDK AQAEEILKLK
EELEDLRRQE GSRQNDMLLL RRQIATLSDE KNKEQEKVTE KEVLKLQNDP QLESEYQQLQ
ESKQRESSLR QQQEEELRFL QAKLKQLEKE RVMAEGKITV KEVLKVEKDL ATEREVSELR
RLYEEEKAKG RSHEREKAEL LRKIQVLEQE NAKVLVQEKV REIVRPDPQT ENEVANLRLE
LVEQERRYRG GEEQLKSCQN ELAALRNRGP QVEVQEVIKE VIKYKTDPET EQELQNLRDE
IVDRTRAIER ADLEIYQLKQ EIQMLKEAKP QVQMKEVVQE VLQYREDPQT REEVESLRAQ
LAEEQKKHMD LERERQIQEE RIREKEEELS QVKEKVVQQE VVKLEQDPAL KAEISCFSQN
IESELHQIDS LRNEMRKLQR RRSELERQLD ELEKERQARR EAELEVQRLK IRLSELEEQE
KETTERVTVK QKVILQQDPQ QEKEHAMLKL ELEEEKHKRQ VLQTELEALR KKLHALENME
VKEKVVFSES VQVDKGDTEY EIQKLKNNLE EESRRKMELD ADISRLEAKL SEVEFNNSKS
SKELDFLREE NHKLHLEKQN LLLEMRRLQS EIELTMAEAR DLKNMSQVES SGSLDSRFQT
LEKELEDLKR LSREKDNEIE QLQNRLQTVA IKREQRENHL RRSIVVIDPD TGREMSPEEA
HRFGLIEWGL YVKLKNQECD WEEITMKGPT GESSVIHDRK SGRKFSIEDA LKSGRLTETQ
YDSYLNKEMS IQELAVLVSG QK
//
