ID H9GBQ2_ANOCA Unreviewed; 752 AA.
AC H9GBQ2;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ring finger and WD repeat domain 3 {ECO:0000313|Ensembl:ENSACAP00000006486.4};
GN Name=RFWD3 {ECO:0000313|Ensembl:ENSACAP00000006486.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006486.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006486.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006486.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006486.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9GBQ2; -.
DR STRING; 28377.ENSACAP00000006486; -.
DR Ensembl; ENSACAT00000006631.4; ENSACAP00000006486.4; ENSACAG00000006627.4.
DR eggNOG; KOG1645; Eukaryota.
DR GeneTree; ENSGT00390000008931; -.
DR HOGENOM; CLU_021009_1_0_1; -.
DR InParanoid; H9GBQ2; -.
DR OrthoDB; 2788028at2759; -.
DR TreeFam; TF323359; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006627; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0097371; F:MDM2/MDM4 family protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR CDD; cd16450; mRING-C3HGC3_RFWD3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037381; RFWD3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16047:SF7; E3 UBIQUITIN-PROTEIN LIGASE RFWD3; 1.
DR PANTHER; PTHR16047; RFWD3 PROTEIN; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 213..257
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..329
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 89..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 81259 MW; 5CC545D2B6EB4B3B CRC64;
MAQEAMEVDL LPAAEEAGRP SGEGRGASGS GAGPGPLAGP GPASPRPSWA AFSGEAEPRR
PPPPPRARGN RARRAPRAAP GRATAPLESY FQVSRTQATD PSDVLAVLNR NSSDEPVVLS
DAESSRSSSS SSSTEVEEDD NEPERALDVA LGPAVLRASG SSQAEPPGDG PSEPEGNPDP
GGSSPATQKT SPLKNPSLAA PPLPLEEESG DTCAICFEEW TNAGEHRLSA LRCGHLFGYS
CIQRWLKGQA GKCPQCNKKA KRSDIVVLYA RTLKALDTSE QEHMKSSLEK EQMLRRKAEL
ESAQSRLQLQ VLTDECSKLR QQVQELKTLM ARHSTPSSQQ PGHSRSCFPG CLSSSQGQHK
YHFERAFLVS QVGNCRVMAY CDPLSCLVIS QPSPQSTFIP GCGIKMMSAV NLKSSQYVPI
HNKQIRGLAF SNRADGLLLS AALDHTLKLT SLTTNTVVQT YNAGRPIWSC CWCLDDTNYI
YAGLVNGSVL VYDLRDTRSQ VQELAPQKSR CPVVSLSYLP RMASASLPYG GLVSGTLEGA
CFWEQKGSGT YKPHHLLLEP GGCVDLQTEA NTRHCLATFR PNRNHNSLRC VVMELTSTQL
TDGAEDAVCS CRPVQTLTAG PTCKLLTKNA IFQSPEDNGS ILVCAGDEAS NSAMVLFSLS
SSYCRNKGNF LKCYVHTYPL CVSSGIIQCL LPQHDKEVEV DLSCYLSSFT SEGVCYCWNS
TTFCKVLDLG RLISLWHLCL PVTLLSTFYL LD
//
