ID H9GC35_ANOCA Unreviewed; 421 AA.
AC H9GC35;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Methyltransferase like 22 {ECO:0000313|Ensembl:ENSACAP00000006784.3};
GN Name=METTL22 {ECO:0000313|Ensembl:ENSACAP00000006784.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006784.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006784.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006784.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006784.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008114989.1; XM_008116782.1.
DR AlphaFoldDB; H9GC35; -.
DR STRING; 28377.ENSACAP00000006784; -.
DR Ensembl; ENSACAT00000006932.3; ENSACAP00000006784.3; ENSACAG00000006944.3.
DR GeneID; 100562833; -.
DR KEGG; acs:100562833; -.
DR CTD; 79091; -.
DR eggNOG; KOG2497; Eukaryota.
DR GeneTree; ENSGT00510000048539; -.
DR HOGENOM; CLU_048361_0_0_1; -.
DR InParanoid; H9GC35; -.
DR TreeFam; TF324844; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006944; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0008276; F:protein methyltransferase activity; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR038899; METTL22.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23108:SF0; METHYLTRANSFERASE-LIKE PROTEIN 22; 1.
DR PANTHER; PTHR23108; METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT REGION 81..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 47594 MW; 8C11787FB9B94A48 CRC64;
MAALTSGARR CFHQKCTLLG AKESEAMDDM TFRSDTVLSD VHLHAPRKRQ FMVRLNAVGQ
PVFLSQFRLL WDSEKEEREF KGKTIRSQDS SAEEEYVQES ASDLGSPSST EEEEGGSLKG
IRALLDEDGD LEVVRKPRFA YAEDEGLPRD KVCPVILMKG GAVLEEDGEE SSSGDIIKIE
HTMATPLEDV GKQVWRGAFL LSDFILCNQD LFKDRTVLEL GGGTGIVSVI TAKAAKTVYC
TDIGEDLLDM CERNIALNKH FTEPAESKVK VRVLDWLQND FCADPDNAYS WSEKEIAELH
DFTTVIVAAD VFYDDDLTDA FFKTLYRITS NLKNPSTVYI SIEKRLNFTL RHMDVACEAY
SYFRSALHDL QDIKDGRTRF AVELLQLSFP QRFVYERVEQ LELWKITADK ICESCTTAHP
L
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