ID   H9GCD2_ANOCA            Unreviewed;       436 AA.
AC   H9GCD2;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=FAM69 N-terminal domain-containing protein {ECO:0000259|SMART:SM01299};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007010.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000007010.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007010.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000007010.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the DIPK family.
CC       {ECO:0000256|ARBA:ARBA00006338}.
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DR   AlphaFoldDB; H9GCD2; -.
DR   Ensembl; ENSACAT00000007161.4; ENSACAP00000007010.3; ENSACAG00000007163.4.
DR   eggNOG; ENOG502QU5P; Eukaryota.
DR   GeneTree; ENSGT00390000006452; -.
DR   HOGENOM; CLU_039177_0_0_1; -.
DR   InParanoid; H9GCD2; -.
DR   TreeFam; TF313319; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000007163; Expressed in dewlap and 6 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   PANTHER; PTHR21093:SF3; DIVERGENT PROTEIN KINASE DOMAIN 1B; 1.
DR   PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        35..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          26..185
FT                   /note="FAM69 N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01299"
SQ   SEQUENCE   436 AA;  49252 MW;  5D6DCF9EA4E7EAB9 CRC64;
     MDYAGLFPSP HHSQFDEPLN YYFLQSRLPG IKVKYLFFVW LGIFVGSWVV YMHYSSYSEL
     CRGHVCQAII CDQYHKGIIS GSTCKDLCEE RTLVFQQCLS SSPTQQVYSG LWKEETEVII
     KCGIEEALKA DAFPESGPRR DVVLFNKPTR GTSMDEFREM LLNFLKSTLG DQPSLGNLVN
     KIIAMADVSR DGKLSLAEAK SIWALVQLND FLLILSLHEK EHASRLLGHC GDLYVTEKIP
     HTSLYTAEVP SFLRPLLPSA VHRLLRRWFS PAWPRRAKIA LGLLEFVEEI FHGTYGTFYI
     CDGAFADMGY NERHDFKVTD LRKVAAESAV RGFLKGRRCE QNADCTYGTD CVAPCDKLMK
     QCKSDVVQPN LAKACGFLQE YLLHGAPSEL KDELGKQLKT CTTLSGLASQ MEVHHSLVLS
     NLKTLLWKTI SDTKYS
//