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Database: UniProt
Entry: H9GDX8_ANOCA
LinkDB: H9GDX8_ANOCA
Original site: H9GDX8_ANOCA 
ID   H9GDX8_ANOCA            Unreviewed;      1176 AA.
AC   H9GDX8;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   12-SEP-2018, entry version 42.
DE   SubName: Full=Potassium calcium-activated channel subfamily M alpha 1 {ECO:0000313|Ensembl:ENSACAP00000008314};
GN   Name=KCNMA1 {ECO:0000313|Ensembl:ENSACAP00000008314};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008314, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000008314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008314};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000008314}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   STRING; 28377.ENSACAP00000008314; -.
DR   Ensembl; ENSACAT00000008493; ENSACAP00000008314; ENSACAG00000008216.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   InParanoid; H9GDX8; -.
DR   OrthoDB; EOG091G148D; -.
DR   TreeFam; TF314283; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000008216; Expressed in 3 organ(s), highest expression level in brain.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005901; C:caveola; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0045794; P:negative regulation of cell volume; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0034465; P:response to carbon monoxide; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0006970; P:response to osmotic stress; IEA:Ensembl.
DR   GO; GO:0060083; P:smooth muscle contraction involved in micturition; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028325; VG_K_chnl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10027:SF28; PTHR10027:SF28; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00984201}.
FT   TRANSMEM     62     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    100    118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    183    204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    219    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       65    274       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1176 AA;  132498 MW;  A9BF7CB211B982CB CRC64;
     MLFAMRNCEV QKISVPAETQ ADGDLKPTDE KEEVVAAEVG WMTSVKDWAG VMISAQTLTG
     RVLVVLVFAL SIGALVIYFI DSSNPIESCQ NFYKDFTLQI DMAFNVFFLL YFGLRFIAAN
     DKLWFWLEVN SVVDFFTVPP VFVSVYLNRS WLGLRFLRAL RLIQFSEILQ FLNILKTSNS
     IKLVNLCSIF ISTWLTAAGF IHLVENSGDP WENFQNNQAL TYWECVYLLM VTMSTVGYGD
     VYAKTTLGRL FMVFFILGGL AMFASYVPEI IELIGNRKKY GGSYSAVSGR KHIVVCGHIT
     LESVSNFLKD FLHKDRDDVN VEIVFLHNIS PNLELEALFK RHFTQVEFFQ GSVLNPHDLA
     RVKIESADAC LILANKYCAD PDAEDASNIM RVISIKNYHP KIRIITQMLQ YHNKAHLLNI
     PSWNWKEGDD AICLAELKLG FIAQSCLAPG LSTMLANLFS MRSFIKIEED TWQKYYLEGV
     ANEMYTEYLS SAFVGLSFPA VCELVFAKLK LLMIAIEYKS EQRESRSRKR ILINPGNHVK
     IQEGTLGFFI ASDAKEVKRA FFYCKACHDD ITDPKRIKKC GCKRPKMSIY KRIKLACCFD
     CGRSERDCSC MSGSVHSNMD TLERAFPLSS VSVNDCSTSL RAFEDEQPTT LSPKKKQRNG
     GMRNSPNSSP KMARHDPLLI PGNEQVDNMD CNVKKYDSTG MFHWCPAKEI DKVILTRSEA
     AMTVLSGHVV VCIFGDVTSA LIGLRNFVMP LRASNFHYHE LKHIVFVGSL EYLRREWETM
     HNFPKVSILP GTPLSRADLR AVNINLCDMC VILSANQNNI DDTSLQDKEC ILASLNIKSM
     QFDDSIGVLQ ANSQGFSPPG MDRSSPDNSP VHGLLRQPSI TTGIDIPIIT ELVNDSNVQF
     LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN DNILTLIRTL VTGGATPELE
     SLIAEENALR GGYSTPQTLA NRDRCRVAQL ALLDGPFADL GDGGCYGDLF CKALKTYNML
     CFGIYRLRDF NPNTPSQCTK RFVIANPPYE FELVPTDWIF CLMQYDHNAG QSRASLSHSS
     HSSYTSSKKS SSVHSLPATA NRQNRTKTRD SREKQNATRM NRMGQAEKKW FTDEPENAYP
     RNIQIKPMST HMANQINQYK STSSLIPPIR EVEDEC
//
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