ID H9GDX9_ANOCA Unreviewed; 808 AA.
AC H9GDX9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Nephronectin {ECO:0000313|Ensembl:ENSACAP00000008316.4};
GN Name=NPNT {ECO:0000313|Ensembl:ENSACAP00000008316.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008316.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000008316.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008316.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000008316.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nephronectin family.
CC {ECO:0000256|ARBA:ARBA00009738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H9GDX9; -.
DR Ensembl; ENSACAT00000008496.4; ENSACAP00000008316.4; ENSACAG00000008437.4.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00930000150973; -.
DR HOGENOM; CLU_036867_0_0_1; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000008437; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR24050:SF19; NEPHRONECTIN; 1.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 265..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 390..430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 663..806
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 507..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 89605 MW; 666299F666ADABC9 CRC64;
MADQPFLPFP FLERNPSEGK ARRAWAPLPA ARRWSLLARN RKEKQERQAK GFSLSLLLLL
LFAFFPPSGA RISNSPKGPP SQFSLQRWEC LKGGGGGGIL RPLPPSLLTS FFPLQPAAER
RTKALLSPPP LPPPFPLFPL SFLPDMDFSW RFILLSWFYL EASGDFDGRW PRQILSTTGL
CRFGGRVDCC WGWVRHSWGQ CQPVCQPGCK HGECVGPNKC KCHPGYTGKT CNQAEHLYAS
SYDWPSEPPF FSPVEHHATK FPWRDLNECG LKPRPCKHRC MNTYGSYKCY CLNGYMLMPD
GSCSNALTCS MANCQYGCDV VKGEIRCRCP SPGLQLASDS RTCIDVDECA TGRVTCPRFR
KCVNTFGSYI CKCHKGFDLM YIGGKYQCHD IDECSLGQYQ CGGFAQCYNT QGSYKCKCKD
GYRGDGMNCI TFAAIENETG FGSVEAHGRS EQDPFNVVLS ETASQREMWA IPKVMIDPSG
PYHVFKGNTT FPKGSGGMNN RIPDTGITRQ PIKPPHIPAV ATAKPTPRTI RPTQRPTVKP
TQKTFTRFVT KPATTKPALK PVTRPPPVTR PPPVTRPPTP PPPKPVTTRI SKVTTQEPLH
ETTIQPGFTA DNSIPIDPQK PRGDVFIPRQ PGVSNNLFDT FEIERGISAD EDEANDDPAI
LVHSCNFDYG LCGWMKERDD DLHWEPVKDD SGGQYLSISE PKGKAGRVAR LVLPLGRLAP
SEDLCLSFRH KVSGMHSGFL QVFVRKTGVH GPAVWGRNSG HGWRQTQITL QGSGIKSVTF
KGQRGKGQTG EIGLDDVNLR KGPCSQDH
//
