ID H9GEU4_ANOCA Unreviewed; 1040 AA.
AC H9GEU4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Integrin subunit alpha 4 {ECO:0000313|Ensembl:ENSACAP00000008942.3};
GN Name=ITGA4 {ECO:0000313|Ensembl:ENSACAP00000008942.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008942.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000008942.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008942.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000008942.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_003227172.1; XM_003227124.3.
DR AlphaFoldDB; H9GEU4; -.
DR STRING; 28377.ENSACAP00000008942; -.
DR Ensembl; ENSACAT00000009133.4; ENSACAP00000008942.3; ENSACAG00000008954.4.
DR GeneID; 100552809; -.
DR KEGG; acs:100552809; -.
DR CTD; 3676; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000158443; -.
DR HOGENOM; CLU_004111_5_0_1; -.
DR OrthoDB; 3816176at2759; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000008954; Expressed in adrenal gland and 10 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 983..1005
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 42..107
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 297..356
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 360..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 421..483
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 468..624
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 628..763
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 785..960
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1040 AA; 114801 MW; E0E4ABEFF749E3E2 CRC64;
MRAPWQQQKQ QAAKEAPFLS PPGLARLLLS LSCCSTAAQA YNLDTLSPLV FQGDNGTLFG
YSVLLHSVGR SPWLVVGAPK ANWSTNTSVV SPGAIYRCQI GKNPERSCEA LQVGDPEGQK
CGKTCLEERD NQWLGVSLSR QPGEDGSIVA CGHRWKNVFY ISEHKLPNGV CYVIPANFRT
LLSQRICPCY KDYVRRYGEK YGSCQAGIAT FYTKDLIIMG APGSDYWTGS IFVYNKTANI
YISYVDDSQV KSGSYLGYAV GAGHFLSPSS TEVIGGAPQQ EQTGKAYIFK IQPRRLSILT
ELKGKKLGSY FGSTVCAVDL NGDGFSDLLV GAPTYSKVRE EGRAYVYINS GSGAKMTELE
TALVGSDLYA ARFGESIANL GDIDNDGFED VAIGAPQEND LEGAIYIYNG RKNGISPVFS
QRIRGHQISN SLRMFGQSIS GKIDVDSNGY SDVAVGAFLS DSAVLLRTRT VVIVEASLKH
PDSVNRTKLD CVLNGQPAVC VNLNLCFNYS GRTVPGYIVL LYNLSLDGGR RPDTAARFYF
SSNGTSETTS GSIKIYNSNN NTCTILQAFM RKDVRDILAP IHVEATYRLG NHVLKGESTD
ELSPLQPVLQ QRKDDDIIHS KFVFARFCSQ ENCSANLQVS GKLAFPRPHE KKSYLSVGNM
KTLMLNVTLY NSGDDAYQAT LHIQLPKGLY FTKILDQEET QINCEVSEKE DHAVRLDCSV
GYLYVDHLSK MDFTFVLDAS SLSRAGDDLT ISINTTCENE VSSNLLLDNS LTLILPQKHE
VELNAHGSVT PTSFVYGPSE ENPPVTCMKE MFNFTFHVSN PGLSLAPAVD LMIQIPNSFV
PSDVKLFNIL DVKTTVGQCI YQNHTRDCTL PEKSENMLQE FIMFLTKLDK RLLYCMKNDP
FCLQILCNFG DMESGKEATV QIHLEATPSL LEMGEASTLI FEIKGKVSAD QSPKVIELYK
SRQTAYVILE GLHNQKTKKS VTLLFIGMGS IVGILLLLVL AFLLWKVGFF KRKYKHLPQE
QNGRESWSFI NSDPNDATDE
//
