ID H9GF31_ANOCA Unreviewed; 1553 AA.
AC H9GF31;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009154.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009154.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009154.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009154.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 28377.ENSACAP00000009154; -.
DR Ensembl; ENSACAT00000009347.4; ENSACAP00000009154.4; ENSACAG00000009159.4.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000154992; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR InParanoid; H9GF31; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000009159; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 299..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 364..383
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 786..806
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 818..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 880..900
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 950..970
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 990..1013
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1063..1090
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1102..1124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1136..1152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1189..1217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1292..1315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 92..248
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 299..528
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 536..582
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 768..1022
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1071..1325
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 45..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 175686 MW; FC6F0CFE618DFDF1 CRC64;
MAIKYIIKDS NINSLLHFFL FPSQALARGI DSISLSSFEM SPLASKISKE RRSRRRRKKS
SGAEDDGEDQ KGPKSESEDG QRRMTVLGFT SGSMENSVKR KASHGSVFSF RLRSRDIGSE
ADFADDDIST VGESESQRGS LLVPRNGRRL SVQSQASHSS PNYTHNGKRN SSVDCNGVVS
LIGGGGSPDP TTPTDVLLPP VTMDKPGTDE TTSPSEEVIK KQFLTPQRIS VDQPEEHFQR
QRAVSAVSII TSAMEELEES QQKCPPCWNH FALRFLIWEC CPMWLLIKEK IKYIIMDPFS
DLTITLCIVM NTLFMAMDHY KMTKEFEDVL NIGNLIFTGI FTTEMICKVI ALHPYYYFQQ
GWNIFDSIIV TLSLMELSLS SMGNVSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL
GNLTVVLAII VFIFAVVGMQ LFGDMYCKNV NKISTTGELP RWHMKDFFHS FLIIFRILCG
EWIETMWDCM RVNGQPLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL SAPDEDGEMN
NLQLAFARIN RGLNHAKRAM WDFCCHVLRQ PKATAEKKAM MKPAHARASC WPPPPPSSFM
VKPLLGYESR SSPACKATGN SSPKCNTPKI CILKFSLQKD YFHQDRQQPP MGQRYRSPAV
RSQASEICEE LSELNTDKQT KTDPPLPSVG QEEVTPRRVV PAACLLHAVY CLSSAMHGAE
EGCSMGSTEI CEKNDEKCIG NPHGIGDIEW PCSFKAWLLH CDALPFQAFE DIYLEERKNI
KTMLEYADKI FTYIFVLEML LKWVAYGFKK YFTNAWCWLD FLIVDVSIML STVLGYDHLA
AMKSLRTLRA MRPLRALSRF ESIRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
GKFGKCINKT EGDEPLNNTI VDNMTECQSL NETGELYWTK VRVNFDNVGA GYLALLQVAT
FKGWMEIMYA AVDSREREQQ PVWEANLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK
KKISGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPLNRF QGFIFDCVLN QAFDVCIMLL
ICLNMITMMV ETDDQSPEKV NILYKINMVF VAIFTAECIS KLVALRHYYF TNGWNIFDFV
VVILSIVGSV LSDIIQKYFF SPTLFRVIRL ARIGRILRLI RGAKGIRTLL FALMMSLPAL
FNIGLLLFLV MFIYAIFGMA NFAYVKHEHG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL
HPILNTGPPY CDPSHQNANG SKGNCGSPAV GILFFVTYII ISFLIVVNMY IAIILENFSV
ATEESTEPLS EDDFDMFYEI WEKFDPEATQ FIEYSALSNF ADALSEPLRI AKPNKIKLIA
MDLPMVSGDR IHCLDILFAF TKRVLGESGE MDALKIQMEE KFMAANPSKI SYEPITTTLR
RKHEEVSAIL IQRAYRSHLF QRSLKQASFL YRQQACNLGD DAPEKEGLIA SMMSENYGRP
IDKSETLSST SFPPSYDSVT RGTSDNFQLR LTDSSKSDLE DALSPDRDKE SIV
//
