ID H9GF73_ANOCA Unreviewed; 669 AA.
AC H9GF73;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009257.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009257.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009257.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009257.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR AlphaFoldDB; H9GF73; -.
DR STRING; 28377.ENSACAP00000009257; -.
DR Ensembl; ENSACAT00000009450.4; ENSACAP00000009257.3; ENSACAG00000009302.4.
DR eggNOG; KOG1870; Eukaryota.
DR GeneTree; ENSGT00940000158829; -.
DR HOGENOM; CLU_004896_0_0_1; -.
DR TreeFam; TF352179; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000009302; Expressed in adrenal gland and 10 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF13; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 20; 1.
DR Pfam; PF06337; DUSP; 2.
DR Pfam; PF00443; UCH; 2.
DR SMART; SM00695; DUSP; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 2.
DR PROSITE; PS51283; DUSP; 2.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 1..440
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 442..535
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 544..647
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT REGION 70..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 74908 MW; 1E9A55BB06DB2E68 CRC64;
RTDKKPALCK SYQKLVSEVW HKKRPSYVVP SSLSHGIKLV NPSFRGYAQQ DTQEFLRCLM
DQLHEELKEP VAAEVRDLEA SEADDKREGD RSPSEDEFLS CDSGSSDRGE GDGQAGKAGG
TGMPEAELLI QDEAGRGISE KERLKDRKFS CSHQRSHSEQ VDEDADVDTS VETGTEGRAS
PDILQPPTPR PASPARTPGI SLVCSPCWID LLFSLFPQVS TTVETFQDLS LPIPGKEDLA
KLHSAIYQNV PAKTGSCAGD NYAASQGWIA FIVEYIRRFV VSCIPSWFWG PVVTLEDCLA
AFFAADELKG DNMYSCERCK KLGFEVLQVP LLLSQILCIH LKRFRHEVMY SFKISSHVSF
PLEGLDLRPF LAKESASQVT TYDLLSVICH HGTAGSGHYI AYCQNVINGQ WYEFDDQYVT
EVHETVVQNA EAYVLFYRKS SEEAVRERQK VVSLATMKEP GLLQFYISRE WLNKFNTFAE
PGPITNHTFL CSHGGIPPNK YHYIDDLVVI LPQNVWEYLY NRFGGGPAVN HLYVCSVCQV
EIEALAKRRK MEIDTFIKLN KAFQAEESPG VIYCISMQWF REWEAFVKGK DNEPPGPIDN
SKIAVAKGSG HVQVKPGADY GQISEETWIY LSTLYGGGPE IAIRQNVAQV QEVETLHGEQ
KIEAETRAA
//