ID H9GF97_ANOCA Unreviewed; 1274 AA.
AC H9GF97;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=FLII actin remodeling protein {ECO:0000313|Ensembl:ENSACAP00000009299.3};
GN Name=FLII {ECO:0000313|Ensembl:ENSACAP00000009299.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009299.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009299.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009299.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009299.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003228356.1; XM_003228308.3.
DR AlphaFoldDB; H9GF97; -.
DR STRING; 28377.ENSACAP00000009299; -.
DR Ensembl; ENSACAT00000009493.3; ENSACAP00000009299.3; ENSACAG00000009333.3.
DR GeneID; 100553018; -.
DR KEGG; acs:100553018; -.
DR CTD; 2314; -.
DR eggNOG; KOG0444; Eukaryota.
DR GeneTree; ENSGT00940000156643; -.
DR HOGENOM; CLU_002568_1_0_1; -.
DR InParanoid; H9GF97; -.
DR TreeFam; TF313468; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000009333; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR GO; GO:0008154; P:actin polymerization or depolymerization; IBA:GO_Central.
DR GO; GO:0051016; P:barbed-end actin filament capping; IBA:GO_Central.
DR GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR CDD; cd11280; gelsolin_like; 2.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF139; PROTEIN FLIGHTLESS-1 HOMOLOG; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 5.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 5.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 508..589
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 628..702
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 757..807
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1080..1148
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1185..1259
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 951..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..982
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 145861 MW; 7EA111207B1F2141 CRC64;
MAATGVLPFI RGVDLSGNDF KGGYFPEHVK SMTSLRWLKL NRTGLCYLPE ELSSLQKLEH
LSVSHNSLTT LHGELSGLPC LRAIVARANS LKNSGVPDDI FQLDDLSVLD LSYNQLTEVP
RELENAKNML VLNLKQNSID NIPNQLFINL TDLLYLDLSD NKLESLPPQM RRLVHLQTLI
LNNNPLLHAQ LRQLPAMVAL QTLHLRNTQR TQSNLPTSLD GLVNLSDVDL SCNELTRVPE
CLYTLSNLRR LNLSTNQISE LSLCIDQWTH LETLNLSRNQ LTSLPSAICK LTKLKKLYLN
SNKLDFDGIP SGIGKLANLE EFMAANNNLE LVPESLCRCA KLKKLVLNKN RLVTLPEAVH
FLIDIEVLDV RENPNLVMPP KPVDRTSEWY NIDFSLQNQL RLAGASPATV AAAAGGSSPR
DPLARKMRLR RRKDSTQDDQ AKQVLKGMSD VAQEKNKKME ENGDLKYTDL KTRRWDQSLE
KPHLNYSEFF TEDVGQLPGI TVWQIENFVP TAVDEAFHGK FYEADCYIIL KTLLDANGSL
NWEIYYWIGQ EASLDKKACS AIHAVNLRNY LGAESRCNRE EMGDESDEFS QVFDHEISYI
EGGTASGFYT VEDLHYVSRL YRVYGKKNIK LEPVPLKGTS LDPRFAFLLD HGLEIYVWRG
GQATLSATTK ARLFAEKINK NERKGKAEIV LLTQTQETPE FWESWGGQPE EIKANVPEDF
RPPRPKLYKV GLGLGYLELP QINYRLSVEH KKRPKVDLLP EMRLLQSLLD TKSVYILDCW
SDVFIWIGRK SPRLVRAAAL KLGQELCSML HRPKHAMVLR NLEGTECQVF KSKFKNWDDV
LKVDYTRNAE SVQKAEGISG KVQKDVEKKD QMKADLTALF LPRQPPMPLA EAEQLMEEWN
EDLDGMEGFV LENKKFARLP EEEFGHFYTQ DCYVFLCRYW VPVECEEDEE EKKKKRKKGV
DGAGGGEDED EEEDEEEEKQ PEEDFQCVVY FWQGREASNM GWLTFTFSLQ KKFENLFPGK
LEVVRMTQQQ ENPKFLSHFK RKFIIHKGKR KAKEDSLQPS LYHIRTNGSA LCTRCIQINT
DSGLLNSEFC FILKVPFEST DNQGIVYTWV GRAADPDEAK LAEDIMNHMF DDSYSKQVIN
EGEEPENFFW VGIGPQKPYD GDAEYMKYSR LFRCSNEKGY FAVSEKCSDF CQDDLADDDI
MLLDNGREVY MWVGTQTSQV EIKLSLKACQ VYIQHMRSKE AAQPRKLRLV RKGNEPPAFT
RCFHAWSVFR KPPA
//
