ID   H9GFE0_ANOCA            Unreviewed;       753 AA.
AC   H9GFE0;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=DENN domain containing 1B {ECO:0000313|Ensembl:ENSACAP00000009412.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009412.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000009412.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009412.4};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000009412.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H9GFE0; -.
DR   STRING; 28377.ENSACAP00000009412; -.
DR   Ensembl; ENSACAT00000009607.4; ENSACAP00000009412.4; ENSACAG00000009544.4.
DR   eggNOG; KOG3569; Eukaryota.
DR   GeneTree; ENSGT00940000155446; -.
DR   HOGENOM; CLU_008196_4_0_1; -.
DR   InParanoid; H9GFE0; -.
DR   TreeFam; TF343037; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000009544; Expressed in testis and 12 other cell types or tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR   GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 6.10.140.1000; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR040032; DENND1A/B/C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR13196:SF24; DENN DOMAIN-CONTAINING PROTEIN 1B; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          20..368
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          490..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..701
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   753 AA;  84245 MW;  795974862500860E CRC64;
     SVRRTISFYE KKNDYKRTFD LVLQVKCQAS ENEDPVVLWK FPEDFGDQVR NIGLIFFLMV
     TQVGQHFTFV LTDIESKQRF GFCRLTQGGK ICLCILSYLP WFEVYYKLLN TLADYLAKDQ
     EDDLNDLLDT WYQHPVPEAN TPISLNLIFI SLCTTQLPLL INLTEYFVAV DVNNMLQLYA
     SMLHERRIII TSSKLSTLTA CVHGSASLLY PMYWQHIYIP VLPPHLLDYC CAPMPYLIGV
     HFSLMEKVKS KSLEDVVMLN VDTNTLETPF NDLSNLPSEV VSALKNKLKK QSTATGDGVA
     RAFLRAQAAL FGSYRDALRY KPGEPVSFCE ESFVKHRSST TKQFLETAVN LQLFKQFIEG
     RLAKLNAGKG FSDVFEEEIS SGGFSGGNSR SYHQWVCKVK KGGALINTAM NKASPAVRTA
     YRYAKDHAKQ GIKEVKSKLK HKETEDEYGT CTSGFAHYTP IYTLPNTQRL NSEKRRLVQA
     RFGHLHPYMH NHDSALDEDA DDEMDRGSKL SSEDSEETSC YLYDSDDSGE IAKTSVPPGE
     MDLLGEILDT LSTHSSDQGK LSGAKSLDFF RSMDDIDYKT KNKSNTPSES NIALLCSSRT
     SETANWNLGQ EDGIFSAKQL LPSPRKYVPS SSHRESLSVL CKGSPTSLSG IDSGDIPASS
     QETVQLCSPG AFQGRKTMWK ETLSNTSADG ISSNLSPNPS TLVPWEREPR TENEILEEGG
     LLHEVVSLCK MTPFNHGLNI SGDRFSNNSG NKA
//