ID H9GFH9_ANOCA Unreviewed; 456 AA.
AC H9GFH9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009508.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009508.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009508.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009508.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; H9GFH9; -.
DR Ensembl; ENSACAT00000009705.4; ENSACAP00000009508.4; ENSACAG00000009702.4.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000164482; -.
DR HOGENOM; CLU_006685_4_0_1; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000009702; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF15; ANOCTAMIN; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 45..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 92..115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 387..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 7..431
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 456 AA; 52621 MW; 474DEDE583A61339 CRC64;
MASPFFSLQE RPRPEFAAMA PQMEQNPVTG VKEPHFPQRD RLSRILTGSV AIATMLCVVM
IFLVSVIMYR GIVSTMMYHT RNTVLMTQAG NIANISSSMV NLVLILLMGQ VYTSLAEKLT
RWEMHRTQTQ HEDAFTFKVF IFQFVNFYSS PFYVAFFKGR FVGYPGQYGT LLGMRNEDCG
PGGCLIELAQ QLFIIMVGKQ IVSNIQEFLL PKLKAWRQKR QLARVRGSQI CQEPKQWEED
FELIECEGLF EEYLEMVLQF GFITIFVAAF PLAPLFALLN NWVEIRLDAQ KFVCEYRRPV
AERAQDIGVW FFLLDVLAQL SVIVNAFLIA FTSDFLPRLL YQYQQDSQLR GYVNFTLAYS
PPNYVVGNHT LCRYKAFRDA HGNYTLFYWK LLAIRLGFII AFEHVVFFCL RLIDWLVPDV
PASLELKVKR ERFLAKQALA DNQDVLLTQA AFYPAA
//
