ID H9GG93_ANOCA Unreviewed; 2241 AA.
AC H9GG93;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Rho guanine nucleotide exchange factor 17 {ECO:0000313|Ensembl:ENSACAP00000010107.3};
GN Name=ARHGEF17 {ECO:0000313|Ensembl:ENSACAP00000010107.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010107.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010107.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010107.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010107.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSACAT00000010314.3; ENSACAP00000010107.3; ENSACAG00000010271.3.
DR GeneTree; ENSGT00940000153798; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000010271; Expressed in hemipenis and 10 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 1290..1465
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2241 AA; 243317 MW; 23C71A957E41A85E CRC64;
MAERRDPLER SSSSSALHRS LSAKRLGRRI GPPGQEGGGG GGGGSREEPR PAAPPPLPNP
DAPSPCQAPC VKAHQPSAPA ILGRRSPVRA ASFSLLSRNV AKISSSSSSS ATSSPASEPP
RTPVRSLSPS VRQLSLRFGE PRGSDAQEEE QQLPARNEER ALPSAGDPRP SLLAGAASPL
DEPLSEARIL GKRGSCGCAE PPASLPGPAA THEADPGGKE LQQVPFASHP PPPPPPPRGL
QTLSPRSSLE ASSALDWPKV TEMRKLFGES FRRPQSAGPS KGEAAQEGGS GPRIVPKGRD
LGSGNWGFPP PPLTPQSQLR GAGTDISGRA HFPPEEHNKE TPPPPPPRSC IPYPGLRGHR
RAAPQGGIAQ REGERPPTQA PHLQWDGLHS NPASSAQQAS GPSCVAPAPA FSTGEISSSS
EEELVGSRPK DSQPSFLSSS LGTLEGNHWQ KSLERSSGSE DEEEGLSASR KPCTRRKKEG
IQGQASRGDL SAGMEWHLKA QEDLCQYICP LPTEEKTEPT PAAPLPCDGN TEGHRLFTRG
LSEGCLLSTS GPLSSASPLP HVSRVSKVSI PPFVPSPSGS RSSSRYSSTE TLKEEELLGG
SWGGQGRSFQ GGLGVFRSPS FNQSSSLARL QSQVRARPKL PLGIVKMKQE LPSFENLQRC
GLEAVESSKH RKSMSNPDIA TETLALLNFL KSDLSELKAR KKGSRANEPA EATLGRRSQS
EAQPLNRCAV GSRPTLKDLT ATLRRAKSFT CSDKPQVPRR FFLQNTMKQS SSELYLSKGR
EGDGLPVVIQ DQYIQEARQV FEKISKIGSQ HDYNFKVDSE GNLSFRKSSE ELSGPESSMT
DEGIVTEVET GPPYSYLNPS VEAWKAANQR RGSQTSQLET NEALLPSHTS RPNNEKDETL
PNNKMAPQGL LEAPLTPSAL RRRRKFPSVG NNGSESSNGS NGEANGETYR SLSDPMPHRR
CSITEDSKNF SVDSNLLGSL NAKSGIPESS ALALSECAGS AASDLSVCSD GVKDYNTVIQ
NIVSQPGAMD KVIDEKGNGK TIKKKSFSDP SRRGELASAG FDGPGEPISE MEQSIPPSSS
EPILSEQREQ IREPEVGRLG SLSEHVLPLQ SEDEMVGEAK NYSFDPKLAD VLSPRIVRRS
SKKRTNRVNG QEHRSEETPE TSGIPPSLNR ARPSSKHVRH TSEPTTFVPI GDTTSPPASS
NQNLHAGPPP GLSRLPLKPY PVLQAPSLED VTKHYMLTLT SGEPPSAGTV DTPRSSPATP
TTSEPKLPRC PKHHEDPGTS ISRSKPQVDM RKHVIMTLLD TEQSYVESLR TLMQGYMKPL
KQPENSILCD PSLVDEIFDQ IPELLEHHEE FLDQISECMQ NWHEKQKVGD ILVQSVSTAA
WTPCACNVGH FASHLSFFFL QQSMRENKEK QALSDLMIKP VQRIPRYELL VKDLLKHTPE
EHPDHPFLLE AQRSIKQVAE RINKGMKSAE EVERNARIVQ EIESHIEGME DVGFSKTAWK
CVTVKAIGGK KDRSLFLFTD LLVCTTLKRK SGSLRRSSMS LYTAASVIDT ASKYKLLWKL
PLEDVDIVKG ASQSTNRESI QKAICRLDED LSTLGQVSKL SETLSFPHQG LDDVLKDLMA
SIHRELAEKQ SLSFTMSFPP NKMELTATKA DSTESYIFEF PNPDARHCFE QAFEDTKKKL
ASNKNCLDPE FLKAIPIMKT RSGMQFSCAS PSHSSPENAY EVWVCNSDGY VGQVCLLSIR
KEPIVETCIA VCSARILCIA SVPGLKRTYR ERPTSLTSPS SEPVQTANLE EPGPQQCLHI
SISGSSLELS EPMDSTNRDL VPFDSDDTDD ESSPSPSGTL QSQASHSTIS SSFGNEEIPS
SKDATAETTS SEEEQDPGAF LPLSSACAQN RNSESPMDGR AMRRSSRGSF TRGSLEDLLS
TDPEAYQSSM WLGTEDGCIH VYQSSDNIRN RKNSMKMQHS ASVTCILYLD NQVFVSLANG
ELIAYQREAG RFWDAQNSKS LSLGSPGSPV TKMVAVSGKL WCGCQNRVII LNTSILQQEH
TFQVGQDSNR SVTCLVSSSV GVWVTLQGSA QVRLYHPSSY DQLAEVDITP PVHKMLAGSD
AIIRQHKAAC LRITALLACK DLLWIGTSAG VVLTLSITAN AASLKTPPLP VGLSQGHTGH
VRFLTSIELP EGFDVLFPLP RDPGTEKSND LEKRDSVRHR PSKSKMLVIS GGDGYEDFRL
TNSSETVGRD DSTNHLLLWR V
//
