ID   H9GGA7_ANOCA            Unreviewed;      1727 AA.
AC   H9GGA7;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Nebulin related anchoring protein {ECO:0000313|Ensembl:ENSACAP00000010139.3};
GN   Name=NRAP {ECO:0000313|Ensembl:ENSACAP00000010139.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010139.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000010139.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010139.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000010139.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_003223476.1; XM_003223428.3.
DR   STRING; 28377.ENSACAP00000010139; -.
DR   Ensembl; ENSACAT00000010347.4; ENSACAP00000010139.3; ENSACAG00000010135.4.
DR   GeneID; 100561114; -.
DR   KEGG; acs:100561114; -.
DR   CTD; 4892; -.
DR   eggNOG; KOG1702; Eukaryota.
DR   GeneTree; ENSGT00940000158418; -.
DR   HOGENOM; CLU_003010_1_0_1; -.
DR   InParanoid; H9GGA7; -.
DR   OrthoDB; 3816962at2759; -.
DR   TreeFam; TF313758; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000010135; Expressed in skeletal muscle tissue and 5 other cell types or tissues.
DR   GO; GO:0005916; C:fascia adherens; IEA:Ensembl.
DR   GO; GO:0005927; C:muscle tendon junction; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051371; F:muscle alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0017166; F:vinculin binding; IEA:Ensembl.
DR   GO; GO:0071691; P:cardiac muscle thin filament assembly; IBA:GO_Central.
DR   CDD; cd09446; LIM_N_RAP; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   InterPro; IPR013998; Nebulin-like.
DR   InterPro; IPR000900; Nebulin_repeat.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR11039; NEBULIN; 1.
DR   PANTHER; PTHR11039:SF39; NEBULIN-RELATED-ANCHORING PROTEIN; 1.
DR   Pfam; PF00412; LIM; 1.
DR   Pfam; PF00880; Nebulin; 18.
DR   PRINTS; PR00510; NEBULIN.
DR   SMART; SM00132; LIM; 1.
DR   SMART; SM00227; NEBU; 43.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR   PROSITE; PS51216; NEBULIN; 29.
PE   4: Predicted;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW   ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT   DOMAIN          4..64
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
SQ   SEQUENCE   1727 AA;  199216 MW;  1A32CAFDF3EB3AF0 CRC64;
     MNIQPCARCG YGVYPAEKIN CIDQTWHKAC FHCETCKMML TVNNFVSHQK RPYCQAHNPK
     NNTFTSVFET PINMNVKKQS EAVSEIKYRE EGERFKSVFH WDMKSKDMEI ARKMQQFKSQ
     KDYEESDSWY SENISDSKMV KLAQAQNTLS NVKYTDEGVD QKGKGSFPAL ITPAYQIAKK
     ANQLSSNVEY KRGHEDRVSK FTSVVDTPDI LHAKFGGQLM SDLKYTEEYE QHRGKGSFPA
     LITPAYQIAK RANELASDVK YHQRYEKEMK GKASQSVGAS KQIIDQFGQD YMDDYEEHRG
     KGSFPAMITP AYLNAKKAND LASDIKYKKD FSQMKGAAHY HSLSAQENLV LKQAQDVNKL
     YSEVEYKKDL ENSKGHSLNY CETPQFRNVS KISKYTSDLK YREHYQNQKG HYEGVGMDRR
     TLHAMKVGSL ASNIAYKSDY THDDVDYNYP ATLTPSYQTT RKLVPLKDVN YRQSIDKLKY
     SSVTTTPQIV QAKISAQQLS DLNYRAQYEK TKTQYTLPQD VPQLVKAKAN AELYSEIKYK
     EGWQKSKGRG FEMKLDSMSL LAAKASRDLA SDIKYKEEYE KTKGKALANK DSRLLHSLQV
     AKMSSEIAYK KDFEKNKSNF YLPMDMVNIQ HAKKAQALAS DLDYRKKLHE YTVVPEDLKT
     QWAKKAYGLQ SELQYKTDLT WMKGVGWIAD GSLNIEQAKK AGELVSEKKY RQRADALKFT
     SVADSSQIKH AKKSQELQSD IAYRSGKEDF LHNYTISKDE PLFTQARINA ANISEKIYKS
     SWEKQKEKGF ELHLDAIPFL TAKAKRDLAS DIKYKENYEK TRGQLIGVKG VNEDSQMAHS
     LHVSKMQSDL EYKKAFEDVK SQYHLSMDMI NLVHAKKAQD LATDRGYKTI AHCYTALPTD
     MKTEWAKWAY GLQSDNRYRA DLNWMKGVGW IATGSLNVKQ AKKAGELISE KKYRQHPYAL
     KFTSIKDTPE MIQARISYNQ AVDRLYKEQG ENVKHHYTQT AELPEIFQAK QNALNISETR
     YKESWSKMRD GGYKLKLDAI PFQTAKATSD IISDYKYKEA FEKTKGQMID SSGLDDINIS
     HSVHAALLQS DINYKKDFDH QKSQFHLPLD MVNIVHAKKA QSLVSEQEYR QLLHSYISLP
     EDVRMRCAKR AYKLQSENIY RSDLNFMRGV GCIVPGTLEI EAKKKASELI SESKYRQQPD
     SFKYTSVTDS PGLLHAKFSN MIANERLYKA AGEDTLHHYT VTLGLPELER AKMNAINVSE
     AKYRESWHNL RAQGYKLTME AIPFQTAKAS REIASDLQYK HNFVQERGKH IGARSIWDDT
     NLLHCLYAAK LQNEQEYKRG SKDISSHYHL PLDMVNLVHA RKAQNLVSDQ DYRTRLHEYT
     VLPEDLKMKW AKGVHLLQSE SRYKSDLNFM KGVGWVALRS PQIENVKKAG ELISETKYRQ
     KPDRLKFTTV TDSLDFTHAK NSYLQCNERL YRAGHVDSMQ NYTLPPDHPD FIRARLNALH
     ISDKQYKTSW EQTRAAGYDL RLDAIPFQTA KASREIASDF RYKEAFLRDR GHQIGLRNVD
     DDPKMAHFLK MGYLQSDNQY KRDFVRNKAQ FKSQLDQPGF MHAKKSQQLA SDVNYRQRLH
     QYTCDPEQLN LKHAKKASTM QSDVKYKSDL NWIKGIGWTP PGSYRVEMAR RAAELAFAQE
     PEHQETLDQY NLDTEQTTSE GSQQVRINPD ASEILQVKRR KMQLIKK
//