ID H9GH73_ANOCA Unreviewed; 590 AA.
AC H9GH73;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=L-amino-acid oxidase {ECO:0000256|ARBA:ARBA00012806};
DE EC=1.4.3.2 {ECO:0000256|ARBA:ARBA00012806};
GN Name=aifm3 {ECO:0000313|Ensembl:ENSACAP00000010903.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010903.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010903.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010903.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010903.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00006442}.
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1
CC subfamily. {ECO:0000256|ARBA:ARBA00005465}.
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DR RefSeq; XP_003226843.1; XM_003226795.3.
DR AlphaFoldDB; H9GH73; -.
DR STRING; 28377.ENSACAP00000010903; -.
DR Ensembl; ENSACAT00000011130.4; ENSACAP00000010903.4; ENSACAG00000011078.4.
DR GeneID; 100566706; -.
DR KEGG; acs:100566706; -.
DR CTD; 150209; -.
DR eggNOG; KOG1336; Eukaryota.
DR GeneTree; ENSGT00940000160448; -.
DR HOGENOM; CLU_003291_4_2_1; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000011078; Expressed in kidney and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0001716; F:L-amino-acid oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IBA:GO_Central.
DR GO; GO:0097194; P:execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd03478; Rieske_AIFL_N; 1.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF8; APOPTOSIS-INDUCING FACTOR 3; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR Pfam; PF00355; Rieske; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 70..165
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 590 AA; 65307 MW; 2B7C9671D35CA4DE CRC64;
MGSCFSKSKP VEVKIEVVLP EKERAKEEMS PNGKASPIIY KANGTSRHYQ LEEHPVALNP
YRNLKDVVEA SVCYVKDLDN GQMREVDLGC GKALLVKENG EFYAMGHKCP HYGAPLVKGV
LSKGRIRCPW HGACFNIGTG DIEDFPGLDS LPKFQVKIEK EKVYIRASKQ ALQTQRRTKV
MGKCISLSNY SISSTNVLII GAGPAGLVCA ETLRQEGFSD RIVMCTMDRH LPYDRPKLSK
SMDSHADQIA LRPKEFFRTY DIEVLTEMQV VAVDVKNKTA VFKDGFKMEY NKLLLATGNT
PKTLSCKGKE VENVFTIRTV EDANRVVKLA TSKNAVVVGA SFLGMEVAAY LSDRAHSVSV
VELEEVPFKK FFGEKVGRAL MKMFENNRVK FYMQTEVSEL REQEGKLKEV VLKSGKVLRA
DVCVIGIGAT PATGFLKQSG VHVDSKGFIA VNKMMQTSIP GVFAAGDAVA FPLSLRNNKK
VNIPHWQMAH MHGRIAALNS TVPYLWTAMF GKSIRYAGHG EGFDDVIIRG DLDELKFVAF
YTKNDEVVAV ASMNYDPLVS KVADVMGAGR TIRKRDVEIG DMSWLTGKGS
//
