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Database: UniProt
Entry: H9GII7_ANOCA
LinkDB: H9GII7_ANOCA
Original site: H9GII7_ANOCA 
ID   H9GII7_ANOCA            Unreviewed;       424 AA.
AC   H9GII7;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   11-DEC-2019, entry version 52.
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 16 {ECO:0000313|Ensembl:ENSACAP00000011872};
GN   Name=KCNJ16 {ECO:0000313|Ensembl:ENSACAP00000011872};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000011872, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000011872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000011872};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E.,
RA   Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., Boissinot S.,
RA   Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., Fujita M.K.,
RA   Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., Heiman D.,
RA   Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., Lara M., Novick P.A.,
RA   Organ C.L., Peach S.E., Poe S., Pollock D.D., de Queiroz K., Sanger T.,
RA   Searle S., Smith J.D., Smith Z., Swofford R., Turner-Maier J., Wade J.,
RA   Young S., Zadissa A., Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B.,
RA   Lander E.S., Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with birds
RT   and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000011872}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AAWZ02022291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003224719.1; XM_003224671.2.
DR   STRING; 28377.ENSACAP00000011872; -.
DR   Ensembl; ENSACAT00000012116; ENSACAP00000011872; ENSACAG00000012133.
DR   GeneID; 100565719; -.
DR   KEGG; acs:100565719; -.
DR   CTD; 3773; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186595; -.
DR   InParanoid; H9GII7; -.
DR   KO; K05009; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000012133; Expressed in 3 organ(s), highest expression level in brain.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR008061; K_chnl_inward-rec_Kir5.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF24; PTHR11767:SF24; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01678; KIR5CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..177
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          185..352
FT                   /note="IRK_C"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   SITE            164
FT                   /note="Role in the control of polyamine-mediated channel
FT                   gating and in the blocking by intracellular magnesium"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ   SEQUENCE   424 AA;  48584 MW;  654B60FBEFF8D55C CRC64;
     MAESGDSNRL IVMEVHQLRH AQSYQDTTSV GLKRVQKRFL QKDGNCNVYF KHIFGEWESY
     VTDIFTTLVD IQWRHMFVIF SLSYILSWLF FGLVFWLIAL QHGDLSSDEE VTPCVDKVHS
     FTGAFLFSLE TQTTIGYGSR CVTEECPAAI LMVILQSVLG CIIDTFIIGA ALAKMATARK
     RAQTIRFSYY ATVGLRDGKL CLMWRVGDFR PNHMVEGTVR AQLLRYVEDR LGRMVLEYKD
     LKLLNDQIIV ATPVTIVHEI NQDSPLYEMD RKTLAKENFE ILVTFVYTGD STGTSHQSRS
     SYVPREILWG HRFNDVLQLK KKYYKVNCLQ FEETTEVYAP FCSAKHLDRK EQEYTSFERT
     SDKEPGTSSA LLGLRARSFS ADTLIIHSEM SDRSAKVPHQ VNTKELPYES ALGTLSRISM
     ESQI
//
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