ID H9GIQ1_ANOCA Unreviewed; 1375 AA.
AC H9GIQ1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Zinc finger protein 536 {ECO:0000313|Ensembl:ENSACAP00000012010.3};
GN Name=ZNF536 {ECO:0000313|Ensembl:ENSACAP00000012010.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012010.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012010.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012010.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012010.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_003225480.1; XM_003225432.3.
DR STRING; 28377.ENSACAP00000012010; -.
DR Ensembl; ENSACAT00000012255.3; ENSACAP00000012010.3; ENSACAG00000012257.3.
DR GeneID; 100553330; -.
DR KEGG; acs:100553330; -.
DR CTD; 9745; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156397; -.
DR HOGENOM; CLU_008125_0_0_1; -.
DR InParanoid; H9GIQ1; -.
DR TreeFam; TF332241; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000012257; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044323; F:retinoic acid-responsive element binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF2; ZINC FINGER PROTEIN 536; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF16606; zf-C2H2_assoc; 1.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 130..157
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 158..180
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 274..302
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 345..372
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 373..400
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 631..658
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 751..778
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 779..806
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 210..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1375 AA; 151359 MW; 92FBC7AD06F0465D CRC64;
MEEASLCLGV SSAVPEADVH LNSSILNGQY SMSQKLHQIT SQLSHAFPEL QNRQNPEEKA
STLLEDKSLA SIANQPISSQ MALLANQLNR EVDTTLNGRV DLQQFLNGQN LGIMSQMSDI
EDDARKNRKY PCPLCGKRFR FNSILSLHMR THTGEKPFKC PYCDHRAAQK GNLKIHLRTH
KLGNLGKGRG RVREENRLLH ELEERAILRD KQMKSSLLQP RSDNKSHPHS QPMPLANCNL
PVPTNHSTPD ISNPVPSPKP ASVQEEVVAT AAGFRCTFCK GKFKKREELD RHIRILHKPY
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGSNGNGEQ AANEFRCEVC GQVFSQAWFL
KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS VKNKSPNDSE VPVSIGSMSQ
EAHANLYSRY LSCLQSGFLP PDKASLSEQN QTYSKGDLPM KEREVLGKLL SPIAGIGHGL
TEGDKHSLLG CLNLVPPLKS SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLTK
EHQIQRSHED TLANAGVMFD KEKREYVLVG ADGSKQKMPA DLVHSTKMGN QRDLSNKLDP
LEGSRDFLSH GMNHGLDFNM QSHSNVKEKP TECPDCGRVF RTYHQVVVHS RVHKRDRKAE
DEIIQASIEE RRGSGSDQES QSVSRSTTPG SSNITEESGM GGGLSQTGSA QEDSPHPSSP
SSSDVGDEVG RSAGIQQPAL LRDRSLGSAM KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK
CPHCDYAGTQ SASLKYHLER HHRERQNGAG PLSGQSQSQD HKEETLNKGS MFIRPEVLRG
AFKSLPGIDF RSGMGSQQWS PGMLSSGEHP GHSVGMSSDV SPDNMKSSDL SSKGTRFSEL
GRAYHSMVGN GVNFQGSLQA FMDNFVLSSL KKEKEMKDKA LSDCLPTKPL GSESGEEKVS
GKARKTEKSQ YEPLDLSVRP DATSLPGSSV TVQDNIAWHG CLFCSFTTSS MELMALHLQA
NHLGKAKRKD GVLGLIRNGK DQSREAIASA NKASLLPTSI QSNKDAAVTN LIGQIDPASE
RMNQGSKESP GEQKNTSWSG HMDSTFYNFA ADFYKQFGVY SGVVGAHNSF TTSETEIKTP
SEDDSTMLLS DSVNKSATDD LSDIASSEDM ESSKEETIDD EDIETESDLM NKPLSSLNKD
SAERGDSIQG AASKASQGLI SPLPLSEKQW HSQSLLPPHE AAQSEMKPEQ AQSPHVLEKQ
VNMLSVLRAY SSDGLAAFNG LASSTGSSGC IKRPDLCGHR PFQCRYCPYS ASQKGNLKTH
VLCVHRMPFD NSQYPDRRFK RSRVDSEASG NFEEPAAVKP GSSAELTEEG SKAQE
//
