ID   H9GIX3_ANOCA            Unreviewed;       467 AA.
AC   H9GIX3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Tubulointerstitial nephritis antigen like 1 {ECO:0000313|Ensembl:ENSACAP00000012225.3};
GN   Name=TINAGL1 {ECO:0000313|Ensembl:ENSACAP00000012225.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012225.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000012225.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012225.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000012225.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   RefSeq; XP_008116111.1; XM_008117904.2.
DR   AlphaFoldDB; H9GIX3; -.
DR   STRING; 28377.ENSACAP00000012225; -.
DR   MEROPS; C01.975; -.
DR   Ensembl; ENSACAT00000012475.4; ENSACAP00000012225.3; ENSACAG00000012412.4.
DR   GeneID; 100559942; -.
DR   KEGG; acs:100559942; -.
DR   CTD; 64129; -.
DR   eggNOG; KOG1544; Eukaryota.
DR   GeneTree; ENSGT00940000160023; -.
DR   HOGENOM; CLU_012184_3_2_1; -.
DR   InParanoid; H9GIX3; -.
DR   OrthoDB; 808912at2759; -.
DR   TreeFam; TF313765; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000012412; Expressed in lung and 11 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0043236; F:laminin binding; IEA:Ensembl.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR036201; Pacifastin_dom_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   PANTHER; PTHR12411:SF270; TUBULOINTERSTITIAL NEPHRITIS ANTIGEN-LIKE; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF57283; PMP inhibitors; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..467
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018671384"
FT   DOMAIN          48..96
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
SQ   SEQUENCE   467 AA;  52712 MW;  20B734ABF28EF53D CRC64;
     MKAFWALVAV LLLPSEAVVA RAPRTRRELA PGLHERGIRD AGGSYCQRHD ACCSGRDDEC
     TVPYLDTICY CDLFCNRTVS DCCPDFWEYC LGIEPPLSVQ KACIRNGFKF PAGATYRDNC
     NLCTCHGNGQ WVCEDHACLI NGDMMDAVNR GNYGWRASNY SQFWGMTLDE GIQYRLGTIK
     PPTSVMNMNE LQMNMDENDV LPSYFNAADK WSGMIHEPLD QGNCAGSWAF STAAVASDRI
     SIHSMGHMTP ALSPQNLLSC NTRHQQGCNG GRIDGAWWFL RRRGVVTDEC YPFSNQETNH
     SPNAPACMMH SRSTGRGKRQ AIARCPNPRS HANEIYQSTP AYRLSSNEKE IMKELMENGP
     VQAILEVHED FFMYRTGIYR HTAVAAGKPE QYRRHGTHSV KITGWGEEQM PDGSNQKYWI
     AANSWGKDWG EHGYFRITRG ENECEIETFV VGVWGRVGME DMHHHKK
//