ID H9GJ25_ANOCA Unreviewed; 288 AA.
AC H9GJ25;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Aquaporin 7 {ECO:0008006|Google:ProtNLM};
GN Name=aqp7 {ECO:0000313|Ensembl:ENSACAP00000012359.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012359.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012359.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012359.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012359.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR RefSeq; XP_008117366.1; XM_008119159.2.
DR RefSeq; XP_008117367.1; XM_008119160.2.
DR RefSeq; XP_008117368.1; XM_008119161.1.
DR AlphaFoldDB; H9GJ25; -.
DR STRING; 28377.ENSACAP00000012359; -.
DR Ensembl; ENSACAT00000012612.4; ENSACAP00000012359.3; ENSACAG00000012515.4.
DR GeneID; 100562966; -.
DR KEGG; acs:100562966; -.
DR CTD; 364; -.
DR eggNOG; KOG0224; Eukaryota.
DR GeneTree; ENSGT00940000159054; -.
DR HOGENOM; CLU_020019_9_1_1; -.
DR InParanoid; H9GJ25; -.
DR OrthoDB; 5490746at2759; -.
DR TreeFam; TF313173; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000012515; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015254; F:glycerol channel activity; IBA:GO_Central.
DR GO; GO:0015204; F:urea transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0015793; P:glycerol transmembrane transport; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR PANTHER; PTHR43829:SF15; AQUAPORIN-7; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR02019; AQUAPORIN7.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000477}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 266..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 288 AA; 31109 MW; CD9E3B638F107BE6 CRC64;
MLEKVIRLVT IRNETVRQGL AEALATYILM TFGLGSVAQV VLGRKEYGQY LSINLGFGFG
VMLGVHAAGG ISGAHMNASI TFANCLMGRL SWYKFPAYVI GQFVGSFLAS CTVFALYYDA
IHEYTGGTLT VTGPTATAGI FSTYPAAYMS IWDGFFNEFI ATTLLLIGVL AINDTKNAAA
LPGTGAFITG LLVVAIGMSM GMNTGYAINP SRDLPPRIFT AIAGWGLDVF LAGNCWWWVP
IVAPTLGSLF GIFIYNIFVD FHNRPQPKTE SSQKNECKSD SLDIDIRL
//
