ID H9GJS1_ANOCA Unreviewed; 1703 AA.
AC H9GJS1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Signal induced proliferation associated 1 like 3 {ECO:0008006|Google:ProtNLM};
GN Name=sipa1l3 {ECO:0000313|Ensembl:ENSACAP00000013016.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013016.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013016.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013016.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013016.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008112027.1; XM_008113820.2.
DR STRING; 28377.ENSACAP00000013016; -.
DR Ensembl; ENSACAT00000013275.4; ENSACAP00000013016.3; ENSACAG00000013123.4.
DR GeneID; 100566172; -.
DR KEGG; acs:100566172; -.
DR CTD; 23094; -.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000159183; -.
DR HOGENOM; CLU_002127_0_0_1; -.
DR InParanoid; H9GJS1; -.
DR OrthoDB; 25782at2759; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000013123; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0003382; P:epithelial cell morphogenesis; IBA:GO_Central.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF15; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 3; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 553..770
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 908..972
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 37..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1638..1693
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 62..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 188691 MW; B6674A99DB56580E CRC64;
MTSYRPVHES GDIGGPGLKG GDYYSPGFWA QNGCSMHADG SASSRPNATT PAMPKMGVRA
RIADWPPKRE GMKDPSTSRD LETPTSVPRG FQNGQFSSGV TFSSGVRGFQ RLVRRRSKDT
EFQDGWPRSP GRGFLPLRNR SSSEITLSEC DMEEAFEPRG VRLSSGLPLF REYGSTSSID
VQGISEQSFY EMLNEFRSGT SVDQPPPPDS FRTSRSTKAE ARNDQDEYPL HHKEKSRKKG
SKGEVMGSDS IFRKLRNVRG DGESSKALVD AEEGVRPWLC QKSFAHYDVQ SMLFDLNEVV
GRRAYVAQRR NTTTGASAAS TTASRSCGLT GLEPAPSFIS TDDLNYKENL DHDPGDNNSN
DLLLSCPHFR NEIGGEQDRK VSFSQASTVS PSGGSCGEGN FAEVSPATYC TNASLSVLEV
PKELQRNISR LKHYSIEHVD LGACYYQDYF CGKEHSNYFG VDEKLGPVAV SIRREKLEDH
REHGPQYQYR IIFRTSELIT LRGSILEDAT PTATKHGTIR GLPLKDALEY VVPELNIHCL
RLALNVPKVT EQLRKLDEQG LCRKHKVGIL YCKANQSSEE EMYNNEEAGP AFEEFLALLG
EKVCLRGFTK YAAQLDTKTD STGTHSLYTT YQGYEVMFHV STMLPYTPNN RQQLLRKRHI
GNDIVTIIFQ EPGAQPFTPQ NIRSHFQHVF IIVRVQNPCT ENVCYSVAVT RSKDVPPFGP
AIPSRAVFRK SDIFRDFLLA KMINAENAAY KSDKFHTMAT RTRQEYLKDL AENCVTSTPI
DSTGKFNLIS LTSKKKEKTK ARIGAEQYSM GAIAWRVLAQ DYSQGMEMEA VLGISNEFIV
LLDLGAEEVV FNCFCADVIG WTPDNYSIKI FYGRGDHIFI QAIDGNTENI KEIVQRLKVM
TSGCETIEMT LRRNGLGQLG FHVKFDGTVA EVEDYGFAWQ AGLRQGSRLV EICKVAVVTL
SHDQMIDWLR TSVTVKVVII PPHDDGTPRR GWAESFKMST MEPKMEPESL PVGYRPPYRS
NSAWQWSGSA THGSSQSSKW AEQPASGQSQ SLTRTPKQST MAPYRESQPP HGKRPVSFPE
TPHAASSSQG ETERMQAYRQ PSSSFSVPGS SGAAYGRFKP SPESSIHRYA GPQRSLMPFD
SLYAHEVTSN GGDSSSSGLA SQESTMEKPK PEPLWHVPVQ SRISATSGSK RTSRHEMAGK
DSPNRHAKGE GQYSSSHSSS NTLSSNASSS HSDERWFDTP DPVEADPDPL AKGGSSDSGI
DATSAKSSQR DKLPKSSPPF GSTQHEASGK RKEPSSGQGW GYRTKGFSIG SGMPARGASS
SINDHLKQSS HNNSNSRATY PAHIYKSSMV EASRAPHMSQ SSSFQLSASV PKSFFSKQNS
RNKHLPAGWK KNNEDTPARP IAFTDPKKQV DLSTKNVFGQ PRLRASLRDL RSPRKTYKSS
IEDDLKKLII MDSSAVEQQE RDLSPQKTLQ RTLSDESLCS GRRDGTYASA YCFEQPLASD
VLFTSTYPSS TLPVRKQQQQ QHQSPNNGNL SEKKSNISAS ELSLSDTRDK SLRRIDPGLM
PLPDTATGLE WSSLVSAAKA YEVQRAVSLF SLNDAVLSPD IPSAHSPVLG HLSLERQPTP
RTTPTMSEEP SADLTGKVYQ LEAMLKQLHT DLQKEKQDKV VLQAEVANLR QNNQRLQEES
QTANEQLRKF AEIFSNAVEK KEL
//
