ID H9GK24_ANOCA Unreviewed; 835 AA.
AC H9GK24;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=C3H1-type domain-containing protein {ECO:0000259|PROSITE:PS50103};
GN Name=zc3h12b {ECO:0000313|Ensembl:ENSACAP00000013370.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013370.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013370.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013370.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013370.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ZC3H12 family.
CC {ECO:0000256|ARBA:ARBA00010922}.
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DR RefSeq; XP_003226461.1; XM_003226413.3.
DR RefSeq; XP_016852326.1; XM_016996837.1.
DR RefSeq; XP_016852327.1; XM_016996838.1.
DR RefSeq; XP_016852328.1; XM_016996839.1.
DR RefSeq; XP_016852329.1; XM_016996840.1.
DR RefSeq; XP_016852330.1; XM_016996841.1.
DR AlphaFoldDB; H9GK24; -.
DR STRING; 28377.ENSACAP00000013370; -.
DR Ensembl; ENSACAT00000013642.4; ENSACAP00000013370.3; ENSACAG00000013582.4.
DR GeneID; 100555362; -.
DR KEGG; acs:100555362; -.
DR CTD; 340554; -.
DR eggNOG; KOG3777; Eukaryota.
DR GeneTree; ENSGT00940000159316; -.
DR HOGENOM; CLU_013020_1_0_1; -.
DR InParanoid; H9GK24; -.
DR OrthoDB; 180910at2759; -.
DR TreeFam; TF315783; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000013582; Expressed in embryonic post-anal tail and 12 other cell types or tissues.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR CDD; cd18729; PIN_Zc3h12-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR040546; Rege-1_UBA-like.
DR InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF27; RIBONUCLEASE ZC3H12B-RELATED; 1.
DR Pfam; PF18561; Regnase_1_C; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR Pfam; PF18039; UBA_6; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 355..380
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 355..380
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 93171 MW; E267E7BCB441BCB5 CRC64;
MTAWSMVEKL KMEKRHSQEE RVADQDGGDC SPESEEWTSS ESEPEQQPPP LRNSGSNPQW
QEKEISHKPH RQLCRSPCLD RPSFSQSSLL QDLKLEENKT SLNKEYQAKI DFAVKLGYAG
DQIQAVLNKL GADALINDIL AELVRLGNKA ENEGQASTGS TSGPPGPGPK ETASPELSLE
DEVVDSSDNL RPIVIDGSNV AMSHGNKEGF SCRGIQLAVD WFLEKGHKDI TVFVPTWRKE
QSRPDAPITD QEILHKLEKE KILVFTPSRR VQGRRVVCYD DRFIVKLAYD SDGIIVSNDN
YRDLQNEKPE WKKFIEERLL MYSFVNDKFM PPDDPLGRHG PSLENFLRKK PVIPEHKKQP
CPYGKKCTYG HKCKYYHPER ANQPLRSVAD ELRISAKLSA VKTMSEGALA KCGTGLVLSK
GDLASEVKRI APKRQSDPSI RSVAVEPEDR LSMARKSEAN SVPSLVSALS VPIIPPSKSH
AAGALNTRSA SSPVPGSSHF THQKSSLEHM SSVQYPPILV TNSHGASINY SDQYPKYESL
GDHGYYSMLS DFSNLSISSM HNTDYYGAEV EQGLYSRNSS PCPDTCLSHT SNDPYSSYGD
LYLGVGDASP EDIKARLPPQ NRLPPFSQGY HEALTRVQSY GTEGSKRPPH KHSTSHLALH
VQHPVVGARS SCPGDYPTPP NVYPSATTQP SRALVMTRMD SISDSRLYES NPTRQKRPPL
CREQHASWDP LPCPTDTYAY HSYPLSSNLM QPCYEPVMVR SMPEKMEQLW RNPWVGVCGE
LQEPHIIPEH QYQTYKNLCN IFPAGVVLSV MEKNPHMTDA QQLAAMIVAK LKTGR
//
