ID H9GKM1_ANOCA Unreviewed; 1099 AA.
AC H9GKM1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Connector enhancer of kinase suppressor of Ras 2 {ECO:0008006|Google:ProtNLM};
GN Name=LOC100566500 {ECO:0000313|Ensembl:ENSACAP00000013805.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013805.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013805.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013805.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013805.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR AlphaFoldDB; H9GKM1; -.
DR STRING; 28377.ENSACAP00000013805; -.
DR Ensembl; ENSACAT00000014087.4; ENSACAP00000013805.3; ENSACAG00000014086.4.
DR eggNOG; KOG1738; Eukaryota.
DR GeneTree; ENSGT00940000164237; -.
DR HOGENOM; CLU_013414_0_0_1; -.
DR InParanoid; H9GKM1; -.
DR TreeFam; TF326495; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000014086; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF12; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 12..77
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 85..179
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 249..331
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 645..744
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 356..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 124232 MW; 2FBB4672152F8CD3 CRC64;
MMALVMEPIS KWTPKQVVDW MKGLDDCLQQ YIKNFEREKI NGEQLLHITH QELEELGVTR
IGHQELILEA VDLLCALNYG LETENLRTLS HKLNASAKNL QNFITGRRRS GHYDGRASRR
LPNDFLTSVV DLIGAAKNLL AWLDRSPFVS VTEYSLLKNN IVQLCLELTT IVQQALSKSF
ACLIDHLLPG SWLSLKLFSA VFMPCTQDCT VYETENKILH VCKTLSGICD HIISLSSDSL
VSQSAHLEVV HLTSIMPSEG LGMYIKSTYD GLHVITGTTE NSPADQCKKI HAGDEVIQVN
HQTVVGWQLK NLVNALREDP NGVILTLKKR PQNTLVSAPA LLKNVRWKPL ALQPVIPTSP
TSNSTTPTST MGLSSKMDNS TLQDVFILSP MSGLYGPRDD IGIVSCDDIS KYGIGKSGMK
GSESPSYFLE HETGKYYTLI EGEGHPVSSE YERGRATGVR RREKTPTHGD LRPVSMPTEY
SWIGDSKEPN MYKRGSRDSE SSLLRYLSDD KILVIQEEPL TQKDNKRDTG RRSRKKGKNS
GSPNYPISPS VLTSTVNVRL EPGQQEALNF SLPENNTVPL YHRAGDTIAG DSERYVSSAV
ERQGSTSMRK SFHYASLRVK SKKWPKGGSL NNSSRRRISC KDLGHGDCEG WLWKKKDAKG
YFTQKWKKYW FVLKDSSLYW YTNQNDEKAE GFISLPEFRI DRAIECRRKH AFKACHPKIK
SFFFATDCLE EMNRWMNRLG LAAIGYTPDD KDIRPDEADY WSESDQEDID GSLTLKQEGP
ATICDTYHRT PSMNSSSPFP EPKHGRHFSS ESTYSHSSAE DSRQDPMGTT HSAGCRPPYR
ERRSWQDLIE TPLTSSGLHF LQTVPPDPEY VSGHLGLSPE RRRQATLPVQ RRHNLEQDGP
FPLVECHRGP SSHTRPQKQR SQSLPRNRDV RVKGRVKPSG ITEERSEEKL PIKKQSSLCE
EENVEEQKES SDGLHELYKS LEQASLSAFG EQRPSTKQEF RRSFVKRCND PVINEKLHRI
RVLRSTLKAK EGDLVVINNL LHDPKLTSKK FKEWKVKNYE FFLDICEYGA ALKAQNGASE
LAAPAPLLTH THSFIETHV
//
