ID H9GKQ7_ANOCA Unreviewed; 363 AA.
AC H9GKQ7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha {ECO:0000256|ARBA:ARBA00040625};
GN Name=cntfr {ECO:0000313|Ensembl:ENSACAP00000013879.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013879.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013879.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013879.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013879.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000256|ARBA:ARBA00010890}.
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DR RefSeq; XP_008116073.1; XM_008117866.2.
DR RefSeq; XP_016851800.1; XM_016996311.1.
DR RefSeq; XP_016851801.1; XM_016996312.1.
DR RefSeq; XP_016851802.1; XM_016996313.1.
DR RefSeq; XP_016851803.1; XM_016996314.1.
DR RefSeq; XP_016851804.1; XM_016996315.1.
DR AlphaFoldDB; H9GKQ7; -.
DR STRING; 28377.ENSACAP00000013879; -.
DR Ensembl; ENSACAT00000014163.4; ENSACAP00000013879.3; ENSACAG00000014122.4.
DR GeneID; 100567737; -.
DR KEGG; acs:100567737; -.
DR CTD; 1271; -.
DR eggNOG; ENOG502QUDK; Eukaryota.
DR GeneTree; ENSGT00940000158864; -.
DR HOGENOM; CLU_047259_0_0_1; -.
DR InParanoid; H9GKQ7; -.
DR OrthoDB; 5346848at2759; -.
DR TreeFam; TF331210; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000014122; Expressed in hemipenis and 11 other cell types or tissues.
DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IBA:GO_Central.
DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR23036:SF21; CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..363
FT /note="Ciliary neurotrophic factor receptor subunit alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003620103"
FT DOMAIN 38..88
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 107..204
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 205..305
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 363 AA; 40379 MW; 39FD8E48A5BF0E67 CRC64;
MAFPVSAACW VVLAAAVALG YVQRHSQQES HVHYAQLGTD VTLQCGSVDP EATVTWTANT
TDLDASHLNG SRLVLHNVDL SQSGQYSCYE GTSWHLKYRV NLKVGTPPKE PVLMCRSNNY
PNGFYCSWHL PSPTYMNDTY DITIIHDSKE IACKKDIPAK NRCYIQYHQV FSSKKYRVTL
TATNPLGSSS TTISFDEFSI VKPDPPESVV AKPIAHNPRR LQVTWQYPSS WPDPDSFPLK
FFLRYRPLII DQWQHVELSD GTSHIITDAY AGKEYIIQVA AKDNEIGTWS DWSVAVHATP
WTEEPKHLTT EAQGTETTTA STSAFMVAPT ARPSDPDDAG NNASVALSLV VSLVLVLFSI
HFI
//
