ID H9GKU4_ANOCA Unreviewed; 1465 AA.
AC H9GKU4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Plexin D1 {ECO:0000313|Ensembl:ENSACAP00000013978.3};
GN Name=PLXND1 {ECO:0000313|Ensembl:ENSACAP00000013978.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013978.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013978.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013978.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013978.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 28377.ENSACAP00000013978; -.
DR Ensembl; ENSACAT00000014264.4; ENSACAP00000013978.3; ENSACAG00000014092.4.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000014092; Expressed in hemipenis and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0002116; C:semaphorin receptor complex; IBA:GO_Central.
DR GO; GO:0017154; F:semaphorin receptor activity; IBA:GO_Central.
DR GO; GO:0043542; P:endothelial cell migration; IBA:GO_Central.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IBA:GO_Central.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IBA:GO_Central.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 811..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..82
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1465 AA; 165628 MW; 1B7C796350A317AF CRC64;
MFTSPGLTSV AVSSVNNYTV VFLGTANGRL LKINFNSFMD VMSRESITIA YGEPVHPIMQ
FDPSDSSYLY LMTSHQIARV KVAACDQYTI CTDCLAAADA YCGWCTLETR CSLQHECANS
DEPYYWISTS GGVQQCPSMT IIPSEINMEK ENTAMIIQMN GSIPSLSGMK MSCDYGNNIE
TVAKVLSQSL NQYVYCNFLP REKYPAFPSN QDHVIVQTSV KVNGKNIVWA NFTIYDCKRT
GNIYPKTACI SCFSAKWKCH WCTRKYTCVS NATECEDSIQ MTNSTDCPQI VPASVAPVST
GTSQDIAITL MNAAFIKDSP LECHFETDRI FEARWVNASA VQCSNVQLHT SDKSHLFPVN
LRLKEKPGQF IDSPQMMIVE IYNCATGSAD CSQCHGREDL GHQCIWSDSS SSCRLNTEVL
QIPGPCPPPE IRKIEPLNGP LEGGTLVTIR GRNLGRRFSD IVNAVIIGNV KCIPLQERYI
VSEEIVCWTG EAIAEFSDVV TVNLSKEGKS RERYSYVLPV VKFISPSAGP KAGGTKITIT
GSNLSVGSEL RVLVNGTKEC TDLSRTDTTI TCTMPSVEFT ATASVCVQFE NKSCIGDNNN
FSYEKNPSIM DINPKKSQIS GGRIITVEGN GFLMAQNVSM VVHTVGKEQT NCKVHSDTVI
TCPSPAASNL TGSKPASVDF YINGRLYTDD HHFPFDHYEE AVHISKFHLE YYPDPQFFTA
KKEKWIKHHP GEPLTLVIHK EPDNLGLESN EYEVKIGLIS CEIQIVSDKV IHCSVNESLS
TSERQLPVTI QVGKFNQTIA MLHLGGSETA ITVSIVVCSI LLLLSVVALF VFCTKSRRAE
RYWQKTLLQM EEMESQIREE IRKGFAELQT DMTDLTKELN RSQGIPFLDY KYFVTRTFFP
KCSSLYEERY ILPSQHLSSQ MGSQVQETHP LLLGEWKIPE NCRPNMEEGI ALFSTLLNNK
HFLIVFVHAL EQQKDFAVRD RCNLASLLTI ALHGKLEYYT SIMKDLLVDL IDASASKNPK
LMLRRTESVV EKMLTNWMSI CMYSFLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT
LNEEWLLREN IEAKPRNLNV SFQGCGMDSL SVRVMDTDTL SQVKEKILEA FCKNIPYSQW
PRVEDVDLEW FATSTDSYIL RDLDDTSVME DGRKKLNTLA HYKIPDGASL AMSLTDNKDT
TLSRVKDLDT EKYFHLVLPT DELNENKRSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD
LFKAILSFRD EKPPVAIKYF FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ
FVFDIDKTDH IDACLSVIAQ AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQKYYK
QIRDMPPLSE QEMNAHLAEE SRKYRNEFNT NVAMTEIYKY AKRYRNQIVS ALDSNPTTRR
TQLQHKFEQV IALMEDNIYE CCSEA
//