ID H9GLH5_ANOCA Unreviewed; 2302 AA.
AC H9GLH5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000014508.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014508.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014508.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014508.4};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014508.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 28377.ENSACAP00000014508; -.
DR Ensembl; ENSACAT00000014803.4; ENSACAP00000014508.4; ENSACAG00000014107.4.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000014107; Expressed in hemipenis and 4 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 23.
DR Gene3D; 2.10.25.10; Laminin; 39.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24040:SF13; FIBROPELLIN-1; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 33.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 39.
DR SMART; SM00179; EGF_CA; 39.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 10.
DR SUPFAM; SSF57581; TB module/8-cys domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 36.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 14.
DR PROSITE; PS51364; TB; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 2..55
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 114..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 155..194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 195..236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 237..277
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 278..318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 324..375
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 387..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 429..470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 471..510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 515..554
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 574..615
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 674..715
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..758
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 759..795
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 801..842
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 884..925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 926..963
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 968..1008
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1009..1047
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1050..1091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1092..1128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1133..1173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1178..1234
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1251..1292
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1293..1330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1339..1391
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1409..1450
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1523..1558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1562..1604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1605..1644
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1645..1686
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1691..1736
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1756..1797
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1798..1837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1879..1922
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1923..1964
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1969..2022
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2034..2075
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2076..2116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2117..2155
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2156..2198
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 159..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 475..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1527..1537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2302 AA; 247548 MW; AC0F735CED68B39C CRC64;
MGTCFSALIG GRCAGELPGH YTKAQCCCDS GRCWAVGQAP EMCPVRGSDE FRRLCVEGLP
AAPGFPISSF PGLLPGFGLF RGPGLPGLPG LGPRSSPFMS HLWVSPGTAT LNQTIDICKH
FTNLCLNGRC IPTPSSYRCE CNMGYKQDVR GECIDMDECS SSPCLHGDCV NTPGSYHCKC
HEGFQSTPTK QACIDMDECI MNGVMCRNGR CVNTDGSFQC ICNAGFEVTP DGKNCADHDE
CATTNMCLNG MCINEDGSFK CICKLGFVLA PNGRYCVDVD ECETPGMCMN GWCLNTEGSF
RCECLGGLAI GPGGRVCVDT HVRSTCYGAL KEGACARPFP GAVTKSECCC ASHEHGFGEP
CLPPRVKDTE FQALCSSGIG ITADGRDINE CALNPDICPN GVCENLRGSY RCICNLGYES
DPSGKDCVDV DECAVNRLLC DNGLCRNTPG SYSCSCPKGF VFRTETDTCE DINECSSNPC
VNGVCRNNAG SFACECSPGS KLDLGGTLCV DSMKGTCWLH IQEGRCEVNI NGATLKSECC
ASLGAAWGSP CERCEADPAC PRGFARMKGV SCEDVNECEV FPGVCTNGLC VNSAGSFRCE
CPPGLSLDAS GRTCLDVRLE QCFLRWAEDE SLPSRMGSGM GHSTPQHGHP QYYAVVIIIG
ALLFRLSPFL PFSDVNECKV FPSLCAHGTC RNTIGSFRCV CSSGFALDAE ERNCTDIDEC
RISPDLCGHG ACVNTPGSFE CECFDGYESG FMMMKNCMDV DECERDPLLC RGGACLNTEG
SFQCLCPPGH ELTAEGSACL DINECSLSDN LCRNGHCVNV IGAYQCACDS GFQATPDRQG
CVDIDECTIM NGGCDTHCAN SEGSYECSCS EGYALMPDKR SCTDIDECED DPDVCDGGQC
TNIPGEYRCL CFDGFMASLD MKMCIDVNEC DLNPNICLHG DCENTKGSFI CHCQLGYFVK
KGTTGCTDID ECEVGAHNCD LHAACINIPG SFRCKCRSGW LGDGLKCNDL DECATEAHSC
NLNANCLNTP GSFRCACRDG FNGDGFSCSD VDECADNVNL CENGQCLNAP GGYRCECEMG
FNPTQDSKAC QDIDECTFQN ICVFGTCQNL PGMFRCACDD GYELDRSGGN CTDVNECADP
VNCINGLCVN TPGSYLCNCP QDFELNPTGV GCVDTRVGNC FLETQDRGDG GISCSAEIGV
GVTRASCCCS LGRAWGNPCE LCPPANTTEY KTLCPGGEGF RPNPITVILE DIDECQELPG
LCQGGNCVNT FGSFQCECPL GYYLNEDTRI CEDIDECSAH IGICGPGTCY NTLGNYTCVC
PPEYMQVNGG NNCMDMRKSL CYRNYNDTCE NELSFNMTKK MCCCSYNIGK AWNKPCEPCP
TPASAEYQIL CGNQAPGFII DIHTGKPIDI DECSEIPAIC SHGVCINQIG SFRCECPIGF
SYNNILLICE GESGPRANPI APYRCECATG YKLSLSEACV GRNECQEIPN VCSHGDCVDT
EGSFICICFN GFKATGDLTM CMDIDECDRQ PCGNGTCKNT VGSYNCLCFP GFELTHNNDC
MDVDECSSLA GQVCRNGRCL NSVGSFRCLC QEGYEHTPDG KNCMDVNECV SLPGTCSPGT
CQNLEGSFRC ICPPGYEVQN DNCIDINECE EEPNICLFGT CTNAPGSFQC ICPPGFVLSD
NGRRCFDTRQ SFCFTRFDHG KCSVPKAFNT TKARCCCSKM PGEGWGDPCE LCPQEGNGRT
TAPGHPSQGQ RQIDTNVNEC SENPGICING ACINTDGSFR CECPFGYNLD YTGVQCVDTD
ECSIGNPCGN GTCTNAVGGF ECACDEGFEP GPMMTCEDIN ECALNPLLCA FRCLNTLGSY
DCTCPAGYTL RHDRRMCKDL DECAEGLDDC EAQGMMCKNL IGTFACVCPP GMQRRPDGEG
CTDENECRTK PGICPNGRCV NAVGSYHCDC NEGFQSSPSG TECLDVRRGL CFTEVLQALC
QMSSTNRQPA TKSECCCAGG RGWGPQCELC PFPGTAPHRK MCPHGTGSAT DGRDIDECRV
LPSLCLHGQC INSLGSFRCH CHAGYGPDLT GTHCQDLDEC SQSPKPCNFL CKNTEGSFLC
SCPRGYSLQE DGKTCKDLDE CATKQHNCQF LCVNVVGGFN CKCPPGFTQH HHSCIDNNEC
TAQPTLCGAK GHCLNSPGSY SCECQKGFAL DGAGSSCEDV DECEGNHRCQ HGCQNVLGGY
RCGCPQGYVQ HYQWNQCVGE WPAGKKGSGT TIEWRILVSH QEDGGIPPQG CWVSHQEYDG
VPPEATGVPP RGWWRPTRGC WF
//
