ID H9GLZ3_ANOCA Unreviewed; 1494 AA.
AC H9GLZ3;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Pleckstrin homology, MyTH4 and FERM domain containing H2 {ECO:0000313|Ensembl:ENSACAP00000014891.2};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSACAP00000014891.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014891.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014891.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014891.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014891.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003224090.1; XM_003224042.2.
DR RefSeq; XP_008113918.1; XM_008115711.1.
DR STRING; 28377.ENSACAP00000014891; -.
DR Ensembl; ENSACAT00000015193.4; ENSACAP00000014891.2; ENSACAG00000015147.4.
DR GeneID; 100552405; -.
DR KEGG; acs:100552405; -.
DR CTD; 130271; -.
DR eggNOG; KOG0248; Eukaryota.
DR GeneTree; ENSGT00940000157675; -.
DR HOGENOM; CLU_001626_3_1_1; -.
DR InParanoid; H9GLZ3; -.
DR OMA; WCILIGK; -.
DR OrthoDB; 4538469at2759; -.
DR TreeFam; TF312866; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000015147; Expressed in hemipenis and 11 other cell types or tissues.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 705..799
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 813..921
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 957..1112
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1123..1453
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 201..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1494 AA; 168723 MW; 4EF013C3758E23D6 CRC64;
MAEFLELDWT VDWKERCVAL ESQLMKFRLQ ASKIRELLAE KMQQLEKQVV DADRQAEKAF
QQVQIMEEKL KAANIQTSES ETRLYKKCQD LEILMQEKDD VIQNLEQQLL DQKQIRVQEA
KIIEEKAAKI KEWVTVKLHE LEVENQNLRM INQNQTEEMR LLQNKLQELQ GKKSVPSTHK
PSEGQRLSSL TFGCFLNRAR SPQQVPKPED PNSSASKQAE LSEGNSNLEK ENQETSSVGP
TMYGNNRNLK PLQQNAFMLE QRQAVKSKDL DSNVSKNSCI TVSDWSSDEE EASKRRSKSR
CASTLSSHTS EEGTGYSRIG SEMYLTASDD SSSFIEEEGF QAQGSMHKKL YSWQQGSPWK
NQNHVIGKSN LESFSDKKDH DSFSDELNKR FQSHKLDYSS SSSEANTPSP ILTPALAPKH
PALMQAVGSD RQLDSPSNLP PPKLRTPSVF ALNAALAKKH FSQPSLCSDK MFGRNRNAIS
MIRPFKPQET DIDQVDGEGT DVLEKMDIDC NDELFTYDAC ETQCVESFDS GDTRTTANSK
PPTPPLHRFP SWESRIYAVA KSGLHFSEAF SVDSFSKSST SSTSYSSSGL YTSLIYKNVT
TPVYTTLKGK AAQISNNPFL DDSSGSEEED SSRSSSRTSE SDSRSRSGPG SPRAMKRGVS
LSSVISEGDY AIPPDAYSTD TDYSEPEQKL PKTCSLSSDN GKNEPLEKSG YLLKMGGKVK
TWKRRWFVLK GGELLYYKSP SDVIRKPQGQ IELNASSRIV RGDGKQTVQL TTEKRTYYLT
ADSPNILEEW IKVLQNVLKV QAASPLFIQP DVKPTMKGLL TKVKHGYSKR VWCMLVGKTL
YYFRSQEDKF PLGQIKLWEA KVEEVDRSCD SDEDYEASGR SLLSTHYTIV THPKEQGPTY
LLIGSKHEKD SWLYHLTVAA GSTNINVGTE FEQLVCKLLN IEGDSTSQIW RHPTLCHSKD
GITSPLTTLP SEALQTEAIK LFKTCQLFIN AAVDSPAIDY HVSLAQSALQ VCLTHPELQN
EICCQLVKQT RRRQPPNQIG PIQAWQLLAL CVGLFLPQHP FLWLIKLHLK KNADSRTEFG
KYAIYCQRCV ERTQRNGDRE ARPSRMEILS TLLRNPYHHS LPFSVPVHFM NGIYQVVGFD
ASTTVEEFLN TLNQDTGMRK PAESGFALFT DDPSGKDVEH CLQGNIKICD IISRWEQASK
EQHPGKCEGT RTVRLTYKNR LYFSMQIRGE TEREKLLLMY QTNDQIVNGL FPVNKDLALE
LAALLAQVEI GDFERPFSTP AGQITSPSKS NQTLKQVMEK FYPKRYRDGC SEEQLRQLCQ
RLSTKWMALR GHSASDCVRI YLAVARKWPF FGAKLFAAKP LPVSTLENTL IWFAVFEDGI
HVLEYTSMKF ITTYLYKNLM TFGGYQDDFM LVVNNVLTQE KPTKKLLFTM AKPKILEITL
LIASYINSCH LQKGYAHHLS APASLSPQAG RQKSNIGCQP FLLKNRPTKG PTLL
//
