ID H9GMG6_ANOCA Unreviewed; 394 AA.
AC H9GMG6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015286.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000015286.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000015286.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000015286.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; H9GMG6; -.
DR STRING; 28377.ENSACAP00000015286; -.
DR Ensembl; ENSACAT00000015597.4; ENSACAP00000015286.3; ENSACAG00000015562.4.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000006337; -.
DR HOGENOM; CLU_025681_0_0_1; -.
DR InParanoid; H9GMG6; -.
DR TreeFam; TF335595; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000015562; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0001880; P:Mullerian duct regression; IBA:GO_Central.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 275..394
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 394 AA; 43803 MW; 7DE8C71A822C175C CRC64;
GTGKTDPPLK GSGRGVGHLS LELALEIRRQ SHPDVPLSPR EAQELLFGFD PKCFTRMTPM
VLLSVKRYPG PTSHPPPRSS FLAASGRLDT VPYLAPSAFP AVGAPLSAPN TSAPSDTRRF
LACLSRFVHR VLSPAADTGS ASRARLRLDF DAMEALPHLR LNLSEEVALE RLVRSEDQLV
VFFPEDGRAL AEDQVENWRL EGPLLRQMME KLREVIRDLK AVPAFRANAE LFRTLTAFCY
LPVTSDSDGE GVPRSKIHSL LLLKALQAVR ARWRESRRAH RSARDSATRR DDDYCQLRDL
QVDLVSTGYI ILPESYNANN CAGPCRSPLS TRVSDYYSHT VFLLRMQEQG SPLDRAPCCV
PVKYAQSHMV TFTSDQGLMV KVYPDMVAKA CGCR
//
