ID H9GNJ9_ANOCA Unreviewed; 975 AA.
AC H9GNJ9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ern1 {ECO:0000313|Ensembl:ENSACAP00000016488.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016488.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016488.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016488.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016488.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008116569.1; XM_008118362.2.
DR AlphaFoldDB; H9GNJ9; -.
DR STRING; 28377.ENSACAP00000016488; -.
DR Ensembl; ENSACAT00000016814.4; ENSACAP00000016488.3; ENSACAG00000016707.4.
DR GeneID; 100566768; -.
DR KEGG; acs:100566768; -.
DR CTD; 2081; -.
DR eggNOG; KOG1027; Eukaryota.
DR GeneTree; ENSGT00940000159761; -.
DR HOGENOM; CLU_004875_1_1_1; -.
DR InParanoid; H9GNJ9; -.
DR OrthoDB; 1630at2759; -.
DR TreeFam; TF313986; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000016707; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IBA:GO_Central.
DR GO; GO:0036498; P:IRE1-mediated unfolded protein response; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF17; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..975
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003620236"
FT DOMAIN 571..832
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 835..963
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 411..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 109681 MW; CA9628273989378C CRC64;
MEPRPLPRLR PAWLVLCLLL WMPSFGSANS VTLPETLLFV STLDGSLHAV SKRTGSIKWT
LKEDPVLQVP LHVEDPRPAF LPDPNDGSLY TLGGKNNEGL TKLPFTIPEL VQASPCRSSD
GILYMGKKQD SWYVVDLVTG EKQQTLTSSF AESLCPSTSL LYLGRTEYTI TMYDTKSKEV
RWNATYFDYA ATLPDEDVQY KMSHFASNGD GLVVTVDSES GDVLWIQNYG SPVVAFYIWQ
REGLWKVMHT NVGVETLRYL TFMSGEVGRI TKWKYPFPKE TEAKSKLMPT LYVGKHSTGL
YASPSMVHEG VAIMPRGSPI PLIEGPKTQG VTIEECVITP STDLKFSSGF KRKNSLHYLR
NHWLLIGHHE TPLSAPTKIL EKFPSNLPKR QENVIPAESD KSAFEEAIDI TGSSTKDLPP
PPPKSTGESP SQPGPRTEDP VDSILKDMAT VILSTFLLIG WVAFVITYPL SVHHQQQRQH
QHFQRQLEEK IQLLKQQPFS PALELTPEGE SLEGLCTRPE GSATSSPNLS PKASNHSAYS
NISASDAGSC LSTEQEEDGS TSTIVVGKIT FNPKDVLGHG AEGTIVYRGT FDSRDVAVKR
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI ALELCAATLQ EYVEQKDFTR
HGLQPIILLQ QTMSGLAYLH SLHIVHRDLK PHNILISMPN AHGKVKAMIS DFGLCKKLAV
GRHSFSRRSG VPGTEGWIAP EILSEDCKDN PTHTVDIFSA GCVFYYVISE GSHPFGKSLQ
RQANILLGAY SLDFLNREKH EDIVAHDLIE QMINMDPQKR PSANCVLKHP FFWSLEKQLQ
FFQDVSDRIE KETLDGPIVK ELERGGRAVV NMDWREHITV PLQTDLRKFR SYKGGSVRDL
LRAMRNKKHH YRELPPEVQE TLGSVPDDFV LYFTSRFPYL LLHTFHAMQI CCQERLFLPY
YIQDSDGQIS PGDAV
//
