ID   H9GP40_ANOCA            Unreviewed;       959 AA.
AC   H9GP40;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSACAP00000016952.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016952.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000016952.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016952.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000016952.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_003225739.2; XM_003225691.3.
DR   AlphaFoldDB; H9GP40; -.
DR   STRING; 28377.ENSACAP00000016952; -.
DR   Ensembl; ENSACAT00000017287.4; ENSACAP00000016952.3; ENSACAG00000017145.4.
DR   GeneID; 100560871; -.
DR   KEGG; acs:100560871; -.
DR   CTD; 114880; -.
DR   eggNOG; KOG1737; Eukaryota.
DR   GeneTree; ENSGT00940000156791; -.
DR   HOGENOM; CLU_007105_4_1_1; -.
DR   InParanoid; H9GP40; -.
DR   OrthoDB; 960at2759; -.
DR   TreeFam; TF320922; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000017145; Expressed in testis and 8 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0097038; C:perinuclear endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   GO; GO:0032374; P:regulation of cholesterol transport; IEA:Ensembl.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          87..182
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          446..473
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   959 AA;  109106 MW;  21B8FA33D52CBD5C CRC64;
     MSSEEKGISP AHKTSTPSHK SASSSSSSQR DSRQSGHILE RNISSGSADL VMGKQLLENE
     PVIISKEPDN WEIIEGLKIG QTNVQKPDKH EGFMLKKRKW PLKGWHKRFF VLDNGMLKYS
     KSPIDTQKGK VHGSIDVGLS VMSIKKKARR IDLDTEEHIY HLKVKSQDSF DAWVSRLRHH
     RLYRQNEIVR SPRDASFHIF PSTSTTESSP AANVAMLEAK VSQNNFPWQP PIPCSNSLSP
     LPATCTTGQS KVVAWLQDSE EMDRCSEDLA HCQSNLVELS KILQNLEILQ RTQSAPNFTD
     MQANCVDKKD KRVTRRWRTK SVSKDAKIQL QEGTTLKSQF SSARRRQRLA AAVATTVPFS
     STMSPVRLHS SNPNLCADIE FQMPPSHVAD PLETSTDYIK LQEEFCLMAQ KVHSLLKSAF
     NSIAIEKEKL KQMVSEHDFT GHSTQITRLR QSLSQALNQN AELRSRLNRI HSDSVLCDQV
     VSVNIIPSPD ESGEQIHVSL PLSQQVSHES RLSMSESVSE FFDAQEVLLS ASSSENEASD
     DESYISDVSD NISEDNTSVA DNISRQILNG ELSGGAFRNG RRTCLPSPCP DTSNINLWNI
     LRNNIGKDLS KVSMPVELNE PLNTLQHLCE ELEYSELLDK AAESDDPYER MVLIAAFATS
     GYASTYYRAG SKPFNPVLGE TYESIREDKG FRFFSEQVSH HPPISACHCE SKNFVFWQDI
     RWKNKFWGKS MEILPIGTLN VTLPKYGDCY VWNKVTTCIH NILSGRRWIE HYGEITIRNT
     KSGVCICKLT FMKVNYWNSN VNEVHGVIMD QEGKVVHRLF GKWHEGLYCG VGPSAKCIWR
     PGSMPTNYER YYGFTRFAIE LNELDPALKD LLPRTDARFR PDQRFLEEGH LEAAATEKQR
     IEELQRSRRR YLEENHMEHV PRFFKKVIDA NQREAWVSND TYWELRKDPG FSKIETLKL
//