ID H9GPN1_ANOCA Unreviewed; 718 AA.
AC H9GPN1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=von Willebrand factor C and EGF domains {ECO:0000313|Ensembl:ENSACAP00000017493.2};
GN Name=VWCE {ECO:0000313|Ensembl:ENSACAP00000017493.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000017493.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000017493.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000017493.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000017493.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H9GPN1; -.
DR STRING; 28377.ENSACAP00000017493; -.
DR Ensembl; ENSACAT00000017838.3; ENSACAP00000017493.2; ENSACAG00000017769.4.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000161089; -.
DR HOGENOM; CLU_013313_1_0_1; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000017769; Expressed in hemipenis and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0098586; P:cellular response to virus; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333:SF1; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF57603; FnI-like domain; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 173..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 382..439
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 497..558
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 564..624
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 625..683
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 276..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 76549 MW; 7217416DE87B4BB0 CRC64;
MGHFGSHCCP RLLPSCHRGG IFSYHLSDIS RRRLGPHVCL SGFGSGCCPG WIPAPGSGQC
TLPLCSFGCG SGFCIAPNLC SCRDGGQGIT YPPGACGEYG CDLACNHGGC QEMARVCPLG
FSMMETANGV RCTDIDECLS ASCEGLCVNT EGGFVCECGS GMQLSADRHS CLDTDECLAT
PCQHHCKNSI GSYRCSCHAG FYLHGNRHSC VDVNECRRPS EKRTCQHSCH NTLGSFICSC
RPGYHLSGDR VSCEGFSKTS LGPSPILQSL QHPPTLLRLS PESPAGPPRV SPPSWAPAPH
SAPRTPPPSP SLSTRLLLPQ ASSPTPSPLL PISFFGTPFL LRTARPLVTM SPLPPSLLQE
EIATPVLPSP SAPLTSLPAL PATCWYEGTL HENGSYWIKQ RCLNCSCESG QVRCQAMMCE
VTCSHAIPAA EGECCPSCRG CLYYGISRTE GEVFSLSEDN CTVCVCLAGN VSCISPECAP
SPCPSSAQSD CCPCQPVECH FRGQTYAEGT EFSLDGDDCT TCVCRQGEVE CSFAPCPTLE
CPQDEWLLAP GQCCFTCRKA APTTGCFVDD NGVEFPIGQI WSPGDPCELC ICQADGSVSC
KRTDCLETCP HPIRIPGQCC PDCSAGCSYA GRIFYNNETF PSVLDPCLSC ICLLGSVACS
PLDCIVFCTY PFHPEGECCP VCHGKRTCCA LLEGSECCFC TPSSLCFMPE KNVVQHRK
//
