ID H9GUX5_ANOCA Unreviewed; 345 AA.
AC H9GUX5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000020986.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000020986.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000020986.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000020986.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR AlphaFoldDB; H9GUX5; -.
DR Ensembl; ENSACAT00000026079.3; ENSACAP00000020986.2; ENSACAG00000022657.3.
DR eggNOG; ENOG502RQEK; Eukaryota.
DR GeneTree; ENSGT01100000263517; -.
DR HOGENOM; CLU_047501_8_0_1; -.
DR InParanoid; H9GUX5; -.
DR TreeFam; TF336617; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000022657; Expressed in lung and 6 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022451};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 251..339
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 345 AA; 39793 MW; E8DD8DD5445E18BA CRC64;
MVNPGLLLVG CFPPGPIPAR CAFYRTRRTL LSLLAMARLL LLRVVALLLG HPGIALLNPA
PGVSSSSSHS LRYFYTAASE DNKMHSSFII VGYVDDQRIC QYDSTVREKR PSVPWMSKVE
EEDPSYWKDE SEESRNAEVF FKESLVIARN RYNQSGGFHT LQQMYGCDLR KDGSKAGYRQ
YAYDGKDFIS FDKETLTWTA ADVEAQTTKR KWDAQSMRNQ YLKAYLEEEC ILWLQKYLEY
GKETLLRTET PEVMVTRKVD HDGMETLICR VGGFYPKEID IEWTRDGEVW TQDVFHGLVS
PNSDGTYYTW RSITVDPKER ERYQCHVEHD GLLKPVDVAW EEPGM
//
