ID H9GZX9_HORSE Unreviewed; 312 AA.
AC H9GZX9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Potassium calcium-activated channel subfamily M regulatory beta subunit 4 {ECO:0000313|Ensembl:ENSECAP00000011467.3};
GN Name=KCNMB4 {ECO:0000313|Ensembl:ENSECAP00000011467.3,
GN ECO:0000313|VGNC:VGNC:58498};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000011467.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000011467.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011467.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000011467.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000011467.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H9GZX9; -.
DR STRING; 9796.ENSECAP00000011467; -.
DR PaxDb; 9796-ENSECAP00000011467; -.
DR Ensembl; ENSECAT00000014352.3; ENSECAP00000011467.3; ENSECAG00000013805.3.
DR VGNC; VGNC:58498; KCNMB4.
DR GeneTree; ENSGT00950000183039; -.
DR HOGENOM; CLU_2325973_0_0_1; -.
DR InParanoid; H9GZX9; -.
DR OMA; RGTAQYP; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000013805; Expressed in cerebellum and 19 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IBA:GO_Central.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0005513; P:detection of calcium ion; IBA:GO_Central.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR10258:SF3; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF03185; CaKB; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 312 AA; 34821 MW; 33966732A3123543 CRC64;
MAKLRVAYEY TEAEDKSLRL GLFLIVSGVV SLFIFGFCWL GPALQGLRAT AANCTVLSVQ
QLREEFECTF TCGSACSGTA HYPCVQVFVR GPEASSRALL HPDERQLLAN PKCSYIPPCK
RENQKNLESV MNWQQYWEEE IGSQPFTCYF NQFQSAWRSQ PDSWGVDVDA ACRQEELLGA
VAVFHLQSTR ALRFPPASPL QPRLHPHALC RAVLNYTWCP EYLPNGTCAL SRASPASTAC
EDFPEAAFSG RLSLTSRPDD VLLHRTHDEI VLLHCFLWPL VTFVVGVLIV VLTICAKSLA
VKAEAMKKRK SS
//
