ID H9H082_MELGA Unreviewed; 404 AA.
AC H9H082;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=TNF receptor superfamily member 25 {ECO:0000313|Ensembl:ENSMGAP00000000759.2};
GN Name=TNFRSF25 {ECO:0000313|Ensembl:ENSMGAP00000000759.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000000759.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000000759.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000000759.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; H9H082; -.
DR Ensembl; ENSMGAT00000001405.2; ENSMGAP00000000759.2; ENSMGAG00000001315.2.
DR GeneTree; ENSGT00940000161888; -.
DR HOGENOM; CLU_053353_0_0_1; -.
DR InParanoid; H9H082; -.
DR TreeFam; TF333916; -.
DR Proteomes; UP000001645; Chromosome 23.
DR Bgee; ENSMGAG00000001315; Expressed in thymus and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022329; TNFR_25.
DR PANTHER; PTHR47220; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR PANTHER; PTHR47220:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01972; TNFACTORR25.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 23..60
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 23..60
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 62..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 62..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 105..149
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 105..149
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 319..400
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 261..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 106..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 404 AA; 44423 MW; 7B939A6CB268794D CRC64;
MLRSQQGLVL PSNRTRRSTE KLSCPSGMTW IPSVGWCCTL CAPGKFLQTP CTRHGNDSVC
VPCPAGTFLS HPNILPKCNA CYMCDHQTFQ TVVSNCSATS NIACGCESGY FRECQNKNDN
CSDFSCKKCK TCPGKLLLQP CSDRQDAQCG SCKPNFYAEG SECRPCHMST PETCGEECQR
VCGHRARGSG LEYILLGLTG PLFLGALAIY HKRKRLLMET PAVSPLPTVS PWNCSGPTAC
MHPIIQRAAA TEVVQCQEWE PGPSMARRSS ESSALLHQQP SRAALPNGTT EPSVPQEPST
AHSPAPPLSS PQRCALLQGS QLYAVINAVP VRRWKEFMRV LELRDTEIEL VEMEVAPFRD
RQYEMLKRWC QQTSATLDRI FAALEHMDLS GCAETLRQSL ALGP
//
