ID H9H2P7_MACMU Unreviewed; 1578 AA.
AC H9H2P7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
GN Name=LOC723314 {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001017.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000001017.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001017.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000001017.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR STRING; 9544.ENSMMUP00000001017; -.
DR Ensembl; ENSMMUT00000001085.4; ENSMMUP00000001017.4; ENSMMUG00000049499.1.
DR VEuPathDB; HostDB:ENSMMUG00000049499; -.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000155739; -.
DR HOGENOM; CLU_001634_4_1_1; -.
DR InParanoid; H9H2P7; -.
DR OMA; RVHYGFQ; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000049499; Expressed in liver and 19 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006956; P:complement activation; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03584; NTR_complement_C4; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 2.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PRINTS; PR00004; ANAPHYLATOXN.
DR SFLD; SFLDG01179; Complement_C3/C4_Like; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 536..570
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1429..1576
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1578 AA; 174129 MW; 981B63DE5E6D9AD9 CRC64;
MRPSTDTITV TVENSHGLRV RKKDVYLPSS IFQDDFVIPD ISEPGTWKIS ARFSDGLESN
SSTQFEVKKY VLPNFEVKIT PGKPYILTVP GHLDEIQLDI QARYIYGKPV QGVAYVRFGL
LDEDGKKTFL RGLESQTKLV NGQSHISLSK AEFQDALGKL NMGITDLLGL RLYVAAAIIE
SPGGEMEEAE LTSWSFVSSP FSLDLSKTKR HLVPGAPFLL QALVREMSGS PASGIPVKVS
ATVSSPGSVP EVRDIQQNTD GSGQVSIPII IPQTISELQL SVSAGSPYPA IARLTVAAPP
SGGPGFLSIE RPDSRPPRVG DTLNLNLRAV GSGATFSHYY YMILSRGQIV FMNREPKRTV
TSVSVFVDHH LAPSFYFVAF YYHGDRPVAN SLRVDVQAGA CEGKLELSVD GAKEYRNGES
VKLHLETDSP ALVALGALDT ALYAAGSKSH KPLNMGKVFE VMNSYDLGCG PGGGDSALQV
FQAAGLAFSD GEQWTFSRKR LGCPKEKTTR RKRNVNFQKA INEKLGQYTS PTAKRCCQDG
VTRLPMRRSC EQRAARVQQP DCREPFLSCC QFAESLRKKN RTRGQVGLQR ALEILQEEDL
IDEDDIPVRS FFPENWLWRV ETVDRFQILT LWLPDSLTTW EIHGLSLSKT KGLCVAAPVQ
LRVFREFHLH LRLPMSVRRF EQLELRPVLY NYLARNLTVS VHVSPVEGLC LAGGGGLAQQ
VLVPAGSARP VAFSVVPTAA AAVSLKVVAR GSFDFPVGDA VSKVLQIEKE GAIHTEELVY
ELNPLDHRGR TLEIPGNSDP NMIPDGDFNS YVRVTASDPL DTLGSEGALS PGGVASLLRL
PQGCGEQTMI YLAPTLAASR YLDKTEQWSA LPPETKDHAV DLIQKGYMRI QQFRKADGSY
AAWLSRGSST WLTAFVLKVL SLAQEQVGGS PEKLQETSKW LLSQQQADGS FQDPCPVIHR
NMQGGLVGSD ETVALTAFVT IALHHGLAVF QDEGAEELKQ RVEASISKAN SFLGEKASAG
LLGAHAAAIT AYALTLTKAS GDLRGVAHNN LMAMAQETGD NLYWGSVTSS QSNAVSPTPA
PRNPADPMPQ APALWIETTA YALLHLLLHE GKAEMADQTA AWLTRQGSFQ GGFRSTQDTV
IALDALSAYW IASHTTEERR LNVTLSSTGR SGFRSHALQL NNRQIRGLEE ELQFSLGSKI
NVKVGGNSKG TLKVLRIYNV LDMKNTTCQD LQIEVTVKGH VEYTMEANED YEDYEYDELP
ARDDPGVPLQ PVTPLQLFEG RRNRRRREAP KVVEEQESRV HYTVCIWRNG KVGLSGMAIA
DITLLSGFHA LRADLEKLTS LSDRYVSHFE TEGPHVLLYF DSVPTSRECV GFEAVQEVPV
GLVQPASAAL YDYYNPERRC SVFYGAPSKS RLLATLCSAE VCQCAEGKCP RQRRALERGL
QDEDGYRMKF ACYYPRVEYG FQVKVLREDS RAAFRLFETK ITQVLHFTKD VKATVNQTRN
FLVRASCRLR LEPGREYLIM GLDGATYDLE GHPQYLLDSN SWIEEMPSER LCRSTRQRAA
CTQLHDFLQE YGTQGCQV
//