GenomeNet

Database: UniProt
Entry: H9H2P7_MACMU
LinkDB: H9H2P7_MACMU
Original site: H9H2P7_MACMU 
ID   H9H2P7_MACMU            Unreviewed;      1578 AA.
AC   H9H2P7;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
GN   Name=LOC723314 {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001017.4, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000001017.4, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001017.4,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000001017.4}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001017.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 9544.ENSMMUP00000001017; -.
DR   Ensembl; ENSMMUT00000001085.4; ENSMMUP00000001017.4; ENSMMUG00000049499.1.
DR   VEuPathDB; HostDB:ENSMMUG00000049499; -.
DR   eggNOG; KOG1366; Eukaryota.
DR   GeneTree; ENSGT00940000155739; -.
DR   HOGENOM; CLU_001634_4_1_1; -.
DR   InParanoid; H9H2P7; -.
DR   OMA; RVHYGFQ; -.
DR   TreeFam; TF313285; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   Bgee; ENSMMUG00000049499; Expressed in liver and 19 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006956; P:complement activation; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd00017; ANATO; 1.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   CDD; cd03584; NTR_complement_C4; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.120.1540; -; 2.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR   InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF01759; NTR; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   PRINTS; PR00004; ANAPHYLATOXN.
DR   SFLD; SFLDG01179; Complement_C3/C4_Like; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00104; ANATO; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          536..570
FT                   /note="Anaphylatoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01178"
FT   DOMAIN          1429..1576
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
SQ   SEQUENCE   1578 AA;  174129 MW;  981B63DE5E6D9AD9 CRC64;
     MRPSTDTITV TVENSHGLRV RKKDVYLPSS IFQDDFVIPD ISEPGTWKIS ARFSDGLESN
     SSTQFEVKKY VLPNFEVKIT PGKPYILTVP GHLDEIQLDI QARYIYGKPV QGVAYVRFGL
     LDEDGKKTFL RGLESQTKLV NGQSHISLSK AEFQDALGKL NMGITDLLGL RLYVAAAIIE
     SPGGEMEEAE LTSWSFVSSP FSLDLSKTKR HLVPGAPFLL QALVREMSGS PASGIPVKVS
     ATVSSPGSVP EVRDIQQNTD GSGQVSIPII IPQTISELQL SVSAGSPYPA IARLTVAAPP
     SGGPGFLSIE RPDSRPPRVG DTLNLNLRAV GSGATFSHYY YMILSRGQIV FMNREPKRTV
     TSVSVFVDHH LAPSFYFVAF YYHGDRPVAN SLRVDVQAGA CEGKLELSVD GAKEYRNGES
     VKLHLETDSP ALVALGALDT ALYAAGSKSH KPLNMGKVFE VMNSYDLGCG PGGGDSALQV
     FQAAGLAFSD GEQWTFSRKR LGCPKEKTTR RKRNVNFQKA INEKLGQYTS PTAKRCCQDG
     VTRLPMRRSC EQRAARVQQP DCREPFLSCC QFAESLRKKN RTRGQVGLQR ALEILQEEDL
     IDEDDIPVRS FFPENWLWRV ETVDRFQILT LWLPDSLTTW EIHGLSLSKT KGLCVAAPVQ
     LRVFREFHLH LRLPMSVRRF EQLELRPVLY NYLARNLTVS VHVSPVEGLC LAGGGGLAQQ
     VLVPAGSARP VAFSVVPTAA AAVSLKVVAR GSFDFPVGDA VSKVLQIEKE GAIHTEELVY
     ELNPLDHRGR TLEIPGNSDP NMIPDGDFNS YVRVTASDPL DTLGSEGALS PGGVASLLRL
     PQGCGEQTMI YLAPTLAASR YLDKTEQWSA LPPETKDHAV DLIQKGYMRI QQFRKADGSY
     AAWLSRGSST WLTAFVLKVL SLAQEQVGGS PEKLQETSKW LLSQQQADGS FQDPCPVIHR
     NMQGGLVGSD ETVALTAFVT IALHHGLAVF QDEGAEELKQ RVEASISKAN SFLGEKASAG
     LLGAHAAAIT AYALTLTKAS GDLRGVAHNN LMAMAQETGD NLYWGSVTSS QSNAVSPTPA
     PRNPADPMPQ APALWIETTA YALLHLLLHE GKAEMADQTA AWLTRQGSFQ GGFRSTQDTV
     IALDALSAYW IASHTTEERR LNVTLSSTGR SGFRSHALQL NNRQIRGLEE ELQFSLGSKI
     NVKVGGNSKG TLKVLRIYNV LDMKNTTCQD LQIEVTVKGH VEYTMEANED YEDYEYDELP
     ARDDPGVPLQ PVTPLQLFEG RRNRRRREAP KVVEEQESRV HYTVCIWRNG KVGLSGMAIA
     DITLLSGFHA LRADLEKLTS LSDRYVSHFE TEGPHVLLYF DSVPTSRECV GFEAVQEVPV
     GLVQPASAAL YDYYNPERRC SVFYGAPSKS RLLATLCSAE VCQCAEGKCP RQRRALERGL
     QDEDGYRMKF ACYYPRVEYG FQVKVLREDS RAAFRLFETK ITQVLHFTKD VKATVNQTRN
     FLVRASCRLR LEPGREYLIM GLDGATYDLE GHPQYLLDSN SWIEEMPSER LCRSTRQRAA
     CTQLHDFLQE YGTQGCQV
//
DBGET integrated database retrieval system