ID H9TN93_SHEEP Unreviewed; 219 AA.
AC H9TN93; A0A6P3CXZ2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
GN Name=GPx5 {ECO:0000313|EMBL:AFG23472.1};
GN Synonyms=GPX5 {ECO:0000313|Ensembl:ENSOARP00000018884.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|EMBL:AFG23472.1};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018884.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018884.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|EMBL:AFG23472.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang C., Chen C., Ren Y., Yue W.;
RT "Cloning, characterization and expression analysis of sheep (Ovis aries)
RT glutathione peroxidase.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOARP00000018884.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000217};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000256|ARBA:ARBA00006926, ECO:0000256|RuleBase:RU000499}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01059152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JQ320282; AFG23472.1; -; mRNA.
DR RefSeq; NP_001254812.1; NM_001267883.1.
DR STRING; 9940.ENSOARP00000018884; -.
DR PaxDb; 9940-ENSOARP00000018884; -.
DR Ensembl; ENSOART00000019152.1; ENSOARP00000018884.1; ENSOARG00000017598.1.
DR GeneID; 100913163; -.
DR KEGG; oas:100913163; -.
DR CTD; 2880; -.
DR eggNOG; KOG1651; Eukaryota.
DR HOGENOM; CLU_029507_2_1_1; -.
DR OMA; HELMNGI; -.
DR OrthoDB; 67394at2759; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000017598; Expressed in vas deferens and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR029759; GPX_AS.
DR InterPro; IPR029760; GPX_CS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592:SF127; EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE; 1.
DR PANTHER; PTHR11592; GLUTATHIONE PEROXIDASE; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000499};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000499};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..219
FT /note="Glutathione peroxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014093852"
FT ACT_SITE 71
FT /evidence="ECO:0000256|PIRSR:PIRSR000303-1"
SQ SEQUENCE 219 AA; 25040 MW; C5B3042A2DA3C943 CRC64;
MTVQLRASCL FLLLLAGFVQ TNYSLEKMDC YKDVKGTIYD YDAFTLNGKE HIQFKQYAGK
HVLFVNVATY CGLTAQYPEL NALQEELKPF GLVVLGFPCN QFGKQEPGEN SEILPGLKYV
RPGGGYVPNF QLFEKGDVNG ETEQKVFTFL KQSCPHPSEF MGSIKHISWE PIMVRDIRWN
FEKFLVGPDG VPVMRWFHRT PVSTVKADIL AYMKQFQTK
//
