ID   H9UEX6_FERPD            Unreviewed;       159 AA.
AC   H9UEX6;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Multisubunit Na+/H+ antiporter, MnhE subunit {ECO:0000313|EMBL:AFG36069.1};
GN   OrderedLocusNames=Ferpe_2022 {ECO:0000313|EMBL:AFG36069.1};
OS   Fervidobacterium pennivorans (strain DSM 9078 / Ven5).
OC   Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=771875 {ECO:0000313|EMBL:AFG36069.1, ECO:0000313|Proteomes:UP000007384};
RN   [1] {ECO:0000313|Proteomes:UP000007384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9078 / Ven5 {ECO:0000313|Proteomes:UP000007384};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Lu M., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Pagani I., Noll K.M., Woyke T.;
RT   "Complete sequence of Fervidobacterium pennivorans DSM 9078.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000256|ARBA:ARBA00006228}.
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DR   EMBL; CP003260; AFG36069.1; -; Genomic_DNA.
DR   AlphaFoldDB; H9UEX6; -.
DR   STRING; 771875.Ferpe_2022; -.
DR   KEGG; fpe:Ferpe_2022; -.
DR   PATRIC; fig|771875.3.peg.2049; -.
DR   eggNOG; COG1863; Bacteria.
DR   HOGENOM; CLU_086615_2_2_0; -.
DR   OrthoDB; 9800498at2; -.
DR   Proteomes; UP000007384; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; NA(+)/H(+) ANTIPORTER SUBUNIT E1; 1.
DR   PANTHER; PTHR34584:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT E1; 1.
DR   Pfam; PF01899; MNHE; 1.
DR   PIRSF; PIRSF019239; MrpE; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   159 AA;  18325 MW;  E4F9F60D9EE5F934 CRC64;
     MSFSVFIVTF FTWLILTWTI DPQEVIVGLI VSFAVSLVFK KYYSIKFNRK FIPGLFKFLF
     VYVPVFIWEM LKANLDVASR VVEPKVKVKP GFVRIKTGLK GDVAKLTLAN SITLTPGTIT
     VDIKDDELYI HWIDVKGTDE ESKKELYGKF ERILKGVYE
//