ID H9UH18_SPIAZ Unreviewed; 883 AA.
AC H9UH18;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Spiaf_0711 {ECO:0000313|EMBL:AFG36811.1};
OS Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Spirochaeta.
OX NCBI_TaxID=889378 {ECO:0000313|EMBL:AFG36811.1, ECO:0000313|Proteomes:UP000007383};
RN [1] {ECO:0000313|Proteomes:UP000007383}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 700263 / DSM 8902 / Z-7692
RC {ECO:0000313|Proteomes:UP000007383};
RX PubMed=23991249; DOI=10.4056/sigs.3607108;
RA Liolos K., Abt B., Scheuner C., Teshima H., Held B., Lapidus A., Nolan M.,
RA Lucas S., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A., Pitluck S.,
RA Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Huntemann M., Pati A.,
RA Chen A., Palaniappan K., Land M., Rohde M., Tindall B.J., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Woyke T.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the halophilic bacterium Spirochaeta africana
RT type strain (Z-7692(T)) from the alkaline Lake Magadi in the East African
RT Rift.";
RL Stand. Genomic Sci. 8:165-176(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP003282; AFG36811.1; -; Genomic_DNA.
DR AlphaFoldDB; H9UH18; -.
DR STRING; 889378.Spiaf_0711; -.
DR KEGG; sfc:Spiaf_0711; -.
DR PATRIC; fig|889378.3.peg.722; -.
DR eggNOG; COG2984; Bacteria.
DR eggNOG; COG5002; Bacteria.
DR HOGENOM; CLU_000445_89_20_12; -.
DR Proteomes; UP000007383; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007383};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..406
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 431..485
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 503..759
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 650..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 98578 MW; F7B6690C52F5DBBF CRC64;
MLLLISVALS GAAEAQPRIL ALHSYHTEYL WTARQIRGLE NALDELLGPT QLFHEFMDAK
RIDPLGYEPD LLNLLRNKYR NITFDLVFVS DEQAYDLYSR HGQQLFPDTP MVFAAVDTID
PRFDRRRPPH TGIYEAVELA PIVRLMQRLH PDTEKFLVLS DDRPGLPGFL NQIEAGRRGW
DAEPIILIAP ERQELDTVLQ KHPKIPMLFL GYFSPPDGIS LSLSESVQLI LNAGRRPIYT
AWDDALDTGV LGGYMTSGYQ HGYAAGEYIA KILADGVAPW ELPIRREGIN RYLIDYPVMR
ELGLQPGSFP PGTIFHNSPE ELFARYRRYL VITIAVIAVL SLMILLLLVN NGRRRIAERH
TRAFRRAVES TAHAVYLTDP AGIITYVNPA FEQLTGYSRS EVVGQNPRLL QSGRMPRDYY
TRLWATIQVG SQWYEQITNQ RKDGQLYTAD QTISPLIGTK GQLEGYVAVQ IDASERLAVQ
DALLQAKMAA EDSDRAKTAF LRTISHELRT PLNGILGFSR LILEQQTDDQ TSDYAKHIVE
AGTQLNSIIT SIIDLSRIES RSIGLETDRV NPVGIVRELV ALYQPRTRDT AIRILDNPAG
SSVPNVYMDP VRFRQLVDIL LDNAVKFTPS GEISIKLRWC SRANSVKPAD AARAKTATQP
TGSPQPEAAA TDEDPARGPQ TGTLAVRIRD TGIGLDPAEI DRIFQPFYQA DSSDARRFGG
SGLGLTIAQR LCTQMGGRLE AHGTPGEGAV FTLLLEGIQP ASQRTDTHNP HQAAADSEPA
SRSFPDALTA ETWLNREIEN FATLKARMIP RDLQSWAQQQ VASGILSDPD SRLGQLLRKL
ADAAENWDVQ RMPRYMADID SFMRELSGED TRNAHHTGEE TSE
//
