ID H9UJQ6_SPIAZ Unreviewed; 1016 AA.
AC H9UJQ6;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Spiaf_1692 {ECO:0000313|EMBL:AFG37749.1};
OS Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Spirochaeta.
OX NCBI_TaxID=889378 {ECO:0000313|EMBL:AFG37749.1, ECO:0000313|Proteomes:UP000007383};
RN [1] {ECO:0000313|Proteomes:UP000007383}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 700263 / DSM 8902 / Z-7692
RC {ECO:0000313|Proteomes:UP000007383};
RX PubMed=23991249; DOI=10.4056/sigs.3607108;
RA Liolos K., Abt B., Scheuner C., Teshima H., Held B., Lapidus A., Nolan M.,
RA Lucas S., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A., Pitluck S.,
RA Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Huntemann M., Pati A.,
RA Chen A., Palaniappan K., Land M., Rohde M., Tindall B.J., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Woyke T.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the halophilic bacterium Spirochaeta africana
RT type strain (Z-7692(T)) from the alkaline Lake Magadi in the East African
RT Rift.";
RL Stand. Genomic Sci. 8:165-176(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP003282; AFG37749.1; -; Genomic_DNA.
DR RefSeq; WP_014455732.1; NC_017098.1.
DR AlphaFoldDB; H9UJQ6; -.
DR STRING; 889378.Spiaf_1692; -.
DR KEGG; sfc:Spiaf_1692; -.
DR PATRIC; fig|889378.3.peg.1678; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_1_12; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000007383; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07431; PHP_PolIIIA; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000313|EMBL:AFG37749.1};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000007383};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..75
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1016 AA; 112343 MW; 3B912E6E54450EC3 CRC64;
MLPHDSTTLL GVRSYYSLLR GACSPEQLCA AAAAEGVSTI GIWDRNNIYG LVRCLQAARE
HGIRPIIGVQ LQLPQEPVVW AVCRTPRGYE RLCELVTGVA AAERQSVDTV AAAQEITVPL
PDRLQPFREG LLYELLQNGW DGLTLLLQDV PALARLQTRS SGLDEQLAAA LVWGAPLHAI
RRAAAELGLP AVAISGGGCW RSEQDRELLH VLRSVETRVP CDDLPALDLQ GLRLPGRAEF
LRWFDAVPEA LRAADDLAAA CEDPGLLERG TVFPEFDGLS RSAAAERLRQ LCLDGVRRRY
GFQLDTASGA TETVAAAGLP AEVAARLRYE LGIISNRGFS SYFLVVHDIV RRCPRTCGRG
SAAASMVSYL LGITHVDPLR HNLFFERFLH AERVDPPDID VDFPWDERIE TLRYVFSRYQ
GHAAMVADHV HFGPRAAFRE AALALGASAA DLRDWTALRE QGVSEGIPRP ILETAARLKG
LPRNLGTHPG GVVITPRPIT SYSSVHLSRG GLPLLAWEKD AAEDVGLVKI DLLGNRSLAV
LRDSLAMIRD NHGVDIPWEE FDPSADPAVE QFVRTGDTVG IFYIESPATR LLLQKMGRAD
FAHLVAASSI IRPAANAWIT EYVSRLRGKP WGMWPQLDRV LADTYGIMVY QEDVSRVAVA
IAGFTAAEAD TLRKVLSRKD RSRRLADYRQ RFFAGCSRNG VPAAVVAELW DMILSFDGYS
FCKAHSASYA LVSCKLAWVK LHYPLEFFTA VLNNGGGFYA WQTYLHAAQR RGLRVRWPDV
NRSQASFTCD GGRLRFGLGW LQHIPERVVQ RLLEERQRRG LFYDFADFIQ RLNPTMVELR
QLVRSGACDS LASGYTRPQL FWQFLRMRST VGQAELLAPE PPPPHIKDYS PEVKLSDEIA
VLGICLSRHP VTALRQSIGG SSRLTASCDL ATHPHGATAR ILGILVTAKE VLTRHHQPMG
FATFEDEYGL VEVVLFPGLY RSGRLVWGSA CLVTGRVLHE FGACSLQAEQ IEWISS
//